Kidney stones are common after bariatric surgery

John C Lieske, Ramila A. Mehta, Dawn S. Milliner, Andrew D Rule, Eric J. Bergstralh, Michael G. Sarr

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Obesity, a risk factor for kidney stones and chronic kidney disease (CKD), is effectively treated with bariatric surgery. However, it is unclear whether surgery alters stone or CKD risk. To determine this we studied 762 Olmsted County, Minnesota residents who underwent bariatric surgery and matched them with equally obese control individuals who did not undergo surgery. The majority of bariatric patients underwent standard Roux-en-Y gastric bypass (RYGB; 78%), with the remainder having more malabsorptive procedures (very long limb RYGB or biliopancreatic diversion/duodenal switch; 14%) or restrictive procedures (laparoscopic banding or sleeve gastrectomy; 7%). The mean age was 45 years with 80% being female. The mean preoperative body mass index (BMI) was 46.7 kg/m2 for both cohorts. Rates of kidney stones were similar between surgery patients and controls at baseline, but new stone formation significantly increased in surgery patients (11.0%) compared with controls (4.3%) during 6.0 years of follow-up. After malabsorptive and standard surgery, the comorbidity-adjusted hazard ratio of incident stones was significantly increased to 4.15 and 2.13, respectively, but was not significantly changed for restrictive surgery. The risk of CKD significantly increased after the malabsorptive procedures (adjusted hazard ratio of 1.96). Thus, while RYGB and malabsorptive procedures are more effective for weight loss, both are associated with increased risk of stones, while malabsorptive procedures also increase CKD risk.Kidney International advance online publication, 29 October 2014; doi:10.1038/ki.2014.352.

Original languageEnglish (US)
JournalKidney International
DOIs
StateAccepted/In press - Oct 29 2014

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Kidney Calculi
Bariatric Surgery
Chronic Renal Insufficiency
Biliopancreatic Diversion
Bariatrics
Gastric Bypass
Gastrectomy
Publications
Comorbidity
Weight Loss
Body Mass Index
Extremities
Obesity
Kidney

ASJC Scopus subject areas

  • Nephrology

Cite this

Lieske, J. C., Mehta, R. A., Milliner, D. S., Rule, A. D., Bergstralh, E. J., & Sarr, M. G. (Accepted/In press). Kidney stones are common after bariatric surgery. Kidney International. https://doi.org/10.1038/ki.2014.352

Kidney stones are common after bariatric surgery. / Lieske, John C; Mehta, Ramila A.; Milliner, Dawn S.; Rule, Andrew D; Bergstralh, Eric J.; Sarr, Michael G.

In: Kidney International, 29.10.2014.

Research output: Contribution to journalArticle

Lieske, John C ; Mehta, Ramila A. ; Milliner, Dawn S. ; Rule, Andrew D ; Bergstralh, Eric J. ; Sarr, Michael G. / Kidney stones are common after bariatric surgery. In: Kidney International. 2014.
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abstract = "Obesity, a risk factor for kidney stones and chronic kidney disease (CKD), is effectively treated with bariatric surgery. However, it is unclear whether surgery alters stone or CKD risk. To determine this we studied 762 Olmsted County, Minnesota residents who underwent bariatric surgery and matched them with equally obese control individuals who did not undergo surgery. The majority of bariatric patients underwent standard Roux-en-Y gastric bypass (RYGB; 78{\%}), with the remainder having more malabsorptive procedures (very long limb RYGB or biliopancreatic diversion/duodenal switch; 14{\%}) or restrictive procedures (laparoscopic banding or sleeve gastrectomy; 7{\%}). The mean age was 45 years with 80{\%} being female. The mean preoperative body mass index (BMI) was 46.7 kg/m2 for both cohorts. Rates of kidney stones were similar between surgery patients and controls at baseline, but new stone formation significantly increased in surgery patients (11.0{\%}) compared with controls (4.3{\%}) during 6.0 years of follow-up. After malabsorptive and standard surgery, the comorbidity-adjusted hazard ratio of incident stones was significantly increased to 4.15 and 2.13, respectively, but was not significantly changed for restrictive surgery. The risk of CKD significantly increased after the malabsorptive procedures (adjusted hazard ratio of 1.96). Thus, while RYGB and malabsorptive procedures are more effective for weight loss, both are associated with increased risk of stones, while malabsorptive procedures also increase CKD risk.Kidney International advance online publication, 29 October 2014; doi:10.1038/ki.2014.352.",
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