TY - JOUR
T1 - Kidney injury during pregnancy
T2 - Associated comorbid conditions and outcomes
AU - Gurrieri, Carmelina
AU - Garovic, Vesna D.
AU - Gullo, Antonino
AU - Bojanic, Katarina
AU - Sprung, Juraj
AU - Narr, Bradly J.
AU - Weingarten, Toby N.
N1 - Funding Information:
This project was supported by NIH/NCRR CTSA Grant Numbers UL1 RR-024150 and KL2 RR-024151. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
PY - 2012/9
Y1 - 2012/9
N2 - Purpose To investigate the characteristics of women who have kidney injury during pregnancy. Methods Medical records of all women who gave birth at our institution between January 1, 2005, and December 31, 2010, were retrospectively reviewed electronically. We identified those who incurred a kidney injury [defined by modified Acute Kidney Injury Network (AKIN) criteria: serum creatinine (sCr) increase ≥0.3 mg/dL] during pregnancy or within 30 days postpartum. Identified case records were reviewed in detail. Results During the study period, 54 women had a kidney injury (0.4 % estimated incidence) with a mean (SD) increase in sCr of 0.46 (0.29) mg/dL; most injuries were AKIN stage 1 with transient increases in sCr. Most of the women (n = 48, 87.3 %) had substantial preexisting or pregnancy-associated comorbid conditions (e.g., kidney disease, hypertension, diabetes), complications (e.g., preeclampsia, HELLP syndrome), or a complicated obstetric course (hemorrhage, infections) that could have contributed to the development of a kidney injury. Two patients had AKIN stage 3 injuries: a previously healthy patient who had a massive hemorrhage during cesarean delivery, and a patient with a renal transplant who had deterioration and eventual postpartum failure of her transplanted kidney. Conclusions The majority of pregnancy-associated kidney injuries were transient and occurred in women with substantial comorbid conditions or complicated pregnancies.
AB - Purpose To investigate the characteristics of women who have kidney injury during pregnancy. Methods Medical records of all women who gave birth at our institution between January 1, 2005, and December 31, 2010, were retrospectively reviewed electronically. We identified those who incurred a kidney injury [defined by modified Acute Kidney Injury Network (AKIN) criteria: serum creatinine (sCr) increase ≥0.3 mg/dL] during pregnancy or within 30 days postpartum. Identified case records were reviewed in detail. Results During the study period, 54 women had a kidney injury (0.4 % estimated incidence) with a mean (SD) increase in sCr of 0.46 (0.29) mg/dL; most injuries were AKIN stage 1 with transient increases in sCr. Most of the women (n = 48, 87.3 %) had substantial preexisting or pregnancy-associated comorbid conditions (e.g., kidney disease, hypertension, diabetes), complications (e.g., preeclampsia, HELLP syndrome), or a complicated obstetric course (hemorrhage, infections) that could have contributed to the development of a kidney injury. Two patients had AKIN stage 3 injuries: a previously healthy patient who had a massive hemorrhage during cesarean delivery, and a patient with a renal transplant who had deterioration and eventual postpartum failure of her transplanted kidney. Conclusions The majority of pregnancy-associated kidney injuries were transient and occurred in women with substantial comorbid conditions or complicated pregnancies.
KW - Acute renal failure
KW - Hemorrhage
KW - Postpartum period
KW - Preeclampsia
KW - Pregnancy
KW - Serum creatinine
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U2 - 10.1007/s00404-012-2323-5
DO - 10.1007/s00404-012-2323-5
M3 - Article
C2 - 22526449
AN - SCOPUS:84867980243
SN - 0932-0067
VL - 286
SP - 567
EP - 573
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 3
ER -