TY - JOUR
T1 - Kidney impairment in fetal growth restriction
T2 - three-dimensional evaluation of volume and vascularization
AU - Senra, Janaína Campos
AU - Yoshizaki, Carlos Tadashi
AU - Doro, Giovana Farina
AU - Ruano, Rodrigo
AU - Gibelli, Maria Augusta Bento Cicaroni
AU - Rodrigues, Agatha Sacramento
AU - Koch, Vera Hermina Kalika
AU - Krebs, Vera Lúcia Jornada
AU - Zugaib, Marcelo
AU - Francisco, Rossana Pulcineli Vieira
AU - Bernardes, Lisandra Stein
N1 - Publisher Copyright:
© 2020 John Wiley & Sons, Ltd.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Objectives: Renal development is impaired in fetal growth restriction (FGR). Renal size can be considered a surrogate of renal function in childhood, and could be impaired in that condition. Our aim was to evaluate the ratio of total renal volume, measured by three-dimensional ultrasound, to estimated fetal weight (TRV/EFW) among fetuses with and without growth restriction. Furthermore, we correlated TRV/EFW with fetal Doppler velocimetry and renal vascularization indexes and evaluated the association of renal volume and vascular parameters with adverse neonatal events in growth-restricted fetuses. Methods: In a retrospective cohort, TRV and renal vascularization of growth-restricted and normal fetuses were evaluated by three-dimensional ultrasonography and VOCAL technique. Independent samples t-tests and Mann-Whitney test were used for comparisons between groups. Logistic regression model was applied to evaluate the association between renal characteristics and adverse neonatal events. Results: Seventy-one growth-restricted fetuses were compared to 194 controls. The TRV/EFW was lower in the growth-restricted group (P <.001). In our sample, this ratio did not correlate with Doppler velocimetry parameters, renal vascular indexes or any adverse neonatal events. Conclusion: The TRV/EFW ratio is decreased in FGR. Further studies are needed to investigate the association of this ratio with long-term renal outcomes.
AB - Objectives: Renal development is impaired in fetal growth restriction (FGR). Renal size can be considered a surrogate of renal function in childhood, and could be impaired in that condition. Our aim was to evaluate the ratio of total renal volume, measured by three-dimensional ultrasound, to estimated fetal weight (TRV/EFW) among fetuses with and without growth restriction. Furthermore, we correlated TRV/EFW with fetal Doppler velocimetry and renal vascularization indexes and evaluated the association of renal volume and vascular parameters with adverse neonatal events in growth-restricted fetuses. Methods: In a retrospective cohort, TRV and renal vascularization of growth-restricted and normal fetuses were evaluated by three-dimensional ultrasonography and VOCAL technique. Independent samples t-tests and Mann-Whitney test were used for comparisons between groups. Logistic regression model was applied to evaluate the association between renal characteristics and adverse neonatal events. Results: Seventy-one growth-restricted fetuses were compared to 194 controls. The TRV/EFW was lower in the growth-restricted group (P <.001). In our sample, this ratio did not correlate with Doppler velocimetry parameters, renal vascular indexes or any adverse neonatal events. Conclusion: The TRV/EFW ratio is decreased in FGR. Further studies are needed to investigate the association of this ratio with long-term renal outcomes.
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U2 - 10.1002/pd.5778
DO - 10.1002/pd.5778
M3 - Article
C2 - 32583885
AN - SCOPUS:85091046527
SN - 0197-3851
VL - 40
SP - 1408
EP - 1417
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
IS - 11
ER -