Kidney impairment in fetal growth restriction: three-dimensional evaluation of volume and vascularization

Janaína Campos Senra, Carlos Tadashi Yoshizaki, Giovana Farina Doro, Rodrigo Ruano, Maria Augusta Bento Cicaroni Gibelli, Agatha Sacramento Rodrigues, Vera Hermina Kalika Koch, Vera Lúcia Jornada Krebs, Marcelo Zugaib, Rossana Pulcineli Vieira Francisco, Lisandra Stein Bernardes

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Renal development is impaired in fetal growth restriction (FGR). Renal size can be considered a surrogate of renal function in childhood, and could be impaired in that condition. Our aim was to evaluate the ratio of total renal volume, measured by three-dimensional ultrasound, to estimated fetal weight (TRV/EFW) among fetuses with and without growth restriction. Furthermore, we correlated TRV/EFW with fetal Doppler velocimetry and renal vascularization indexes and evaluated the association of renal volume and vascular parameters with adverse neonatal events in growth-restricted fetuses. Methods: In a retrospective cohort, TRV and renal vascularization of growth-restricted and normal fetuses were evaluated by three-dimensional ultrasonography and VOCAL technique. Independent samples t-tests and Mann-Whitney test were used for comparisons between groups. Logistic regression model was applied to evaluate the association between renal characteristics and adverse neonatal events. Results: Seventy-one growth-restricted fetuses were compared to 194 controls. The TRV/EFW was lower in the growth-restricted group (P <.001). In our sample, this ratio did not correlate with Doppler velocimetry parameters, renal vascular indexes or any adverse neonatal events. Conclusion: The TRV/EFW ratio is decreased in FGR. Further studies are needed to investigate the association of this ratio with long-term renal outcomes.

Original languageEnglish (US)
Pages (from-to)1408-1417
Number of pages10
JournalPrenatal Diagnosis
Volume40
Issue number11
DOIs
StatePublished - Oct 1 2020

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

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