Kidney glomerular filtration rate plasticity after transplantation

Aleksandar Denic, Andrew D. Rule, François Gaillard

Research output: Contribution to journalReview articlepeer-review

Abstract

Since the first living donor kidney transplantation about six decades ago, significant progress has been made in terms of extending allograft survival. However, to date, only a small number of studies have compared the functional changes of the donated kidney to that of the remaining kidney. Although relatively small, the study by Gonzalez Rinne et al. demonstrated the adaptive capacity of the transplanted kidney in 30 donor-recipient pairs. The glomerular filtration rate (GFR) in both donors and recipients was obtained 12 months after transplantation and the authors identified three scenarios: (i) where donors had a higher GFR than recipients; (ii) where donors had a lower GFR than recipients; and (iii) where donors had a similar GFR to recipients. The mechanisms mediating GFR adaptability after kidney transplantation seem to be associated with body surface area (including sex differences in body surface area). Microstructural analysis of human and animal models of renal physiology provides some clues to the physiological adaptation of the transplanted organ. The nephron number from endowment and age-related loss and the adaptive ability for compensatory glomerular hyperfiltration likely play a major role.

Original languageEnglish (US)
Pages (from-to)841-844
Number of pages4
JournalClinical Kidney Journal
Volume15
Issue number5
DOIs
StatePublished - May 1 2022

Keywords

  • body surface area
  • donor
  • GFR
  • kidney transplantation
  • recipient

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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