Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias

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11 Scopus citations

Abstract

PURPOSE OF REVIEW: To describe recent studies on Krüppel-like factor transcription factors and their relationship with gastrointestinal neoplasias, in particular pancreatic cancer. RECENT FINDINGS: Krüppel-like factor proteins are a subfamily of transcription factors characterized by the presence of a conserved DNA-binding domain comprising three Krüppel-like zinc fingers. Each distinct family member differs in its ability to regulate transcription, and, as a consequence, to influence cellular processes including cell growth and differentiation. Recently, a number of publications have provided evidence of the implication of Krüppel-like factor proteins in gastrointestinal carcinogenesis. SUMMARY: This article will focus on the results of studies in the field published in the last year.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalCurrent Opinion in Gastroenterology
Volume22
Issue number5
DOIs
StatePublished - Sep 2006

Keywords

  • Krüppel-like factor 11
  • Krüppel-like factors
  • Pancreatic cancer
  • Tumor suppressor
  • Tumorigenesis

ASJC Scopus subject areas

  • Gastroenterology

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