Ketolide treatment of Haemophilus influenzae experimental pneumonia

Kerryl E. Piper, Mark S. Rouse, James M. Steckelberg, Walter R. Wilson, Robin Patel

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The MICs of HMR 3004 and HMR 3647: at which 90% of beta-lactamase- producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase- producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.

Original languageEnglish (US)
Pages (from-to)708-710
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number3
DOIs
StatePublished - Mar 1999

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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