Abstract
The MICs of HMR 3004 and HMR 3647: at which 90% of beta-lactamase- producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase- producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 708-710 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 43 |
| Issue number | 3 |
| State | Published - 1999 |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Ketolide treatment of Haemophilus influenzae experimental pneumonia. / Piper, Kerryl E.; Rouse, Mark S.; Steckelberg, James M.; Wilson, Walter R.; Patel, Robin.
In: Antimicrobial Agents and Chemotherapy, Vol. 43, No. 3, 1999, p. 708-710.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ketolide treatment of Haemophilus influenzae experimental pneumonia
AU - Piper, Kerryl E.
AU - Rouse, Mark S.
AU - Steckelberg, James M.
AU - Wilson, Walter R.
AU - Patel, Robin
PY - 1999
Y1 - 1999
N2 - The MICs of HMR 3004 and HMR 3647: at which 90% of beta-lactamase- producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase- producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.
AB - The MICs of HMR 3004 and HMR 3647: at which 90% of beta-lactamase- producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase- producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.
UR - http://www.scopus.com/inward/record.url?scp=0033055963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033055963&partnerID=8YFLogxK
M3 - Article
C2 - 10049297
AN - SCOPUS:0033055963
VL - 43
SP - 708
EP - 710
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 3
ER -