Ketolide treatment of Haemophilus influenzae experimental pneumonia

Kerryl E. Piper; Mark S. Rouse; James M. Steckelberg; Walter R. Wilson; Robin Patel

doi:10.1128/aac.43.3.708

Ketolide treatment of Haemophilus influenzae experimental pneumonia

Kerryl E. Piper, Mark S. Rouse, James M. Steckelberg, Walter R. Wilson, Robin Patel

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The MICs of HMR 3004 and HMR 3647: at which 90% of beta-lactamase- producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase- producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.

Original language	English (US)
Pages (from-to)	708-710
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	43
Issue number	3
DOIs	https://doi.org/10.1128/aac.43.3.708
State	Published - Mar 1999

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Ketolide treatment of Haemophilus influenzae experimental pneumonia",

abstract = "The MICs of HMR 3004 and HMR 3647: at which 90% of beta-lactamase- producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase- producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.",

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AU - Patel, Robin

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