Ketolide treatment of Haemophilus influenzae experimental pneumonia

Kerryl E. Piper, Mark S. Rouse, James M. Steckelberg, Walter R. Wilson, Robin Patel

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The MICs of HMR 3004 and HMR 3647: at which 90% of beta-lactamase- producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase- producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.

Original languageEnglish (US)
Pages (from-to)708-710
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number3
StatePublished - 1999

Fingerprint

Ketolides
Haemophilus influenzae
Pneumonia
beta-Lactamases
Pristinamycin
Azithromycin
Clarithromycin
Erythromycin
Ciprofloxacin
Theoretical Models
Lung
RU 64004
telithromycin

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Piper, K. E., Rouse, M. S., Steckelberg, J. M., Wilson, W. R., & Patel, R. (1999). Ketolide treatment of Haemophilus influenzae experimental pneumonia. Antimicrobial Agents and Chemotherapy, 43(3), 708-710.

Ketolide treatment of Haemophilus influenzae experimental pneumonia. / Piper, Kerryl E.; Rouse, Mark S.; Steckelberg, James M.; Wilson, Walter R.; Patel, Robin.

In: Antimicrobial Agents and Chemotherapy, Vol. 43, No. 3, 1999, p. 708-710.

Research output: Contribution to journalArticle

Piper, KE, Rouse, MS, Steckelberg, JM, Wilson, WR & Patel, R 1999, 'Ketolide treatment of Haemophilus influenzae experimental pneumonia', Antimicrobial Agents and Chemotherapy, vol. 43, no. 3, pp. 708-710.
Piper, Kerryl E. ; Rouse, Mark S. ; Steckelberg, James M. ; Wilson, Walter R. ; Patel, Robin. / Ketolide treatment of Haemophilus influenzae experimental pneumonia. In: Antimicrobial Agents and Chemotherapy. 1999 ; Vol. 43, No. 3. pp. 708-710.
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