Ketamine: Behavioral effects of subanesthetic doses

Mohamed M. Ghoneim; James V. Hinrichs; Steven P. Mewaldt; Ronald C. Petersen

doi:10.1097/00004714-198504000-00003

Ketamine: Behavioral effects of subanesthetic doses

Mohamed M. Ghoneim, James V. Hinrichs, Steven P. Mewaldt, Ronald C. Petersen

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was due to interference with retrieval processes. Recovery was virtually complete 60 minutes after administration. The incidence of adverse reactions was high. Benzodiazepines need to be administered even when ketamine is used in subanesthetic doses.

Original language	English (US)
Pages (from-to)	70-77
Number of pages	8
Journal	Journal of Clinical Psychopharmacology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1097/00004714-198504000-00003
State	Published - Apr 1985

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)

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AU - Petersen, Ronald C.

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AB - Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was due to interference with retrieval processes. Recovery was virtually complete 60 minutes after administration. The incidence of adverse reactions was high. Benzodiazepines need to be administered even when ketamine is used in subanesthetic doses.

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Ketamine: Behavioral effects of subanesthetic doses

Abstract

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