Keratinocyte growth factor induces pancreatic ductal epithelial proliferation

Eunhee S. Yi, Songmei Yin, Donna L. Harclerode, Adriana Bedoya, Nadim B. Bikhazi, Regina M. Housley, Sharon L. Aukerman, Charles F. Morris, Glenn F. Pierce, Thomas R. Ulich

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Keratinocyte growth factor (KGF) causes a proliferation of pancreatic ductal epithelial cells in adult rats daily systemic administration for 1 to 2 weeks. Even before the proliferation of intralobular ducts is histologically evident, KGF also induces proliferating cell nuclear antigen expression within the ductal epithelium of intercalated, intralobular, and interlobular ducts. KGF also causes incorporation of 5-bromodeoxyuridine in ductal epithelial cells. Epithelial cell proliferation is histologically most prominent at the level of the intralobular ducts adjacent to and within the islets of Langerhans. Pancreatic ductal proliferation is not histologically apparent in rats sacrificed 7 to 10 days after the cessation of KGF administration. The pancreatic hormones insulin, glucagon, somatostatin, and pancreatic polypeptide are normally distributed within islets that demonstrate intrainsular ductal proliferation. The proliferating ductal epithelium does not show endocrine differentiation as evidenced by the lack of immunoreactivity for pancreatic hormones. KGF is a potent in vivo mitogen for pancreatic ductal epithelial cells.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalAmerican Journal of Pathology
Volume145
Issue number1
StatePublished - Jul 1994
Externally publishedYes

Fingerprint

Fibroblast Growth Factor 7
Epithelial Cells
Pancreatic Hormones
Epithelium
Pancreatic Polypeptide
Proliferating Cell Nuclear Antigen
Bromodeoxyuridine
Somatostatin
Glucagon
Islets of Langerhans
Mitogens
Cell Proliferation
Insulin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Yi, E. S., Yin, S., Harclerode, D. L., Bedoya, A., Bikhazi, N. B., Housley, R. M., ... Ulich, T. R. (1994). Keratinocyte growth factor induces pancreatic ductal epithelial proliferation. American Journal of Pathology, 145(1), 80-85.

Keratinocyte growth factor induces pancreatic ductal epithelial proliferation. / Yi, Eunhee S.; Yin, Songmei; Harclerode, Donna L.; Bedoya, Adriana; Bikhazi, Nadim B.; Housley, Regina M.; Aukerman, Sharon L.; Morris, Charles F.; Pierce, Glenn F.; Ulich, Thomas R.

In: American Journal of Pathology, Vol. 145, No. 1, 07.1994, p. 80-85.

Research output: Contribution to journalArticle

Yi, ES, Yin, S, Harclerode, DL, Bedoya, A, Bikhazi, NB, Housley, RM, Aukerman, SL, Morris, CF, Pierce, GF & Ulich, TR 1994, 'Keratinocyte growth factor induces pancreatic ductal epithelial proliferation', American Journal of Pathology, vol. 145, no. 1, pp. 80-85.
Yi ES, Yin S, Harclerode DL, Bedoya A, Bikhazi NB, Housley RM et al. Keratinocyte growth factor induces pancreatic ductal epithelial proliferation. American Journal of Pathology. 1994 Jul;145(1):80-85.
Yi, Eunhee S. ; Yin, Songmei ; Harclerode, Donna L. ; Bedoya, Adriana ; Bikhazi, Nadim B. ; Housley, Regina M. ; Aukerman, Sharon L. ; Morris, Charles F. ; Pierce, Glenn F. ; Ulich, Thomas R. / Keratinocyte growth factor induces pancreatic ductal epithelial proliferation. In: American Journal of Pathology. 1994 ; Vol. 145, No. 1. pp. 80-85.
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