Kelch-like Protein 11 antibodies in seminoma-Associated paraneoplastic encephalitis

Caleigh Mandel-brehm, Divyanshu Dubey, Thomas J. Kryzer, Brian D. O'donovan, Baouyen Tran, Sara E. Vazquez, Hannah A. Sample, Kelsey C. Zorn, Lillian M. Khan, Ian O. Bledsoe, Andrew Mckeo, Samuel J. Pleasure, Vanda A Lennon, Joseph L. Derisi, Michael R. Wilson, Sean J Pittock

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia. An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of programmable phage display. Immunoassays were used to identify KLHL11 IgG in 12 other men with similar neurologic features and testicular disease. Immunostaining of the patient's IgG on mouse brain tissue showed sparse but distinctive points of staining in multiple brain regions, with enrichment in perivascular and perimeningeal tissues. The onset of the neurologic syndrome preceded the diagnosis of seminoma in 9 of the 13 patients. An age-adjusted estimate of the prevalence of autoimmune KLHL11 encephalitis in Olmsted County, Minnesota, was 2.79 cases per 100,000 men.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalNew England Journal of Medicine
Volume381
Issue number1
DOIs
StatePublished - Jul 4 2019

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mandel-brehm, C., Dubey, D., Kryzer, T. J., O'donovan, B. D., Tran, B., Vazquez, S. E., Sample, H. A., Zorn, K. C., Khan, L. M., Bledsoe, I. O., Mckeo, A., Pleasure, S. J., Lennon, V. A., Derisi, J. L., Wilson, M. R., & Pittock, S. J. (2019). Kelch-like Protein 11 antibodies in seminoma-Associated paraneoplastic encephalitis. New England Journal of Medicine, 381(1), 47-54. https://doi.org/10.1056/NEJMoa1816721