Kelch-like Protein 11 antibodies in seminoma-Associated paraneoplastic encephalitis

Caleigh Mandel-brehm, Divyanshu Dubey, Thomas J. Kryzer, Brian D. O'donovan, Baouyen Tran, Sara E. Vazquez, Hannah A. Sample, Kelsey C. Zorn, Lillian M. Khan, Ian O. Bledsoe, Andrew Mckeo, Samuel J. Pleasure, Vanda A Lennon, Joseph L. Derisi, Michael R. Wilson, Sean J Pittock

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia. An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of programmable phage display. Immunoassays were used to identify KLHL11 IgG in 12 other men with similar neurologic features and testicular disease. Immunostaining of the patient's IgG on mouse brain tissue showed sparse but distinctive points of staining in multiple brain regions, with enrichment in perivascular and perimeningeal tissues. The onset of the neurologic syndrome preceded the diagnosis of seminoma in 9 of the 13 patients. An age-adjusted estimate of the prevalence of autoimmune KLHL11 encephalitis in Olmsted County, Minnesota, was 2.79 cases per 100,000 men.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalNew England Journal of Medicine
Volume381
Issue number1
DOIs
StatePublished - Jul 4 2019

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Seminoma
Encephalitis
Antibodies
Testicular Diseases
Immunoglobulin G
Proteins
Diplopia
Vertigo
Brain
Ataxia
Nervous System Diseases
Immunoassay
Autoantibodies
Bacteriophages
Nervous System
Staining and Labeling

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kelch-like Protein 11 antibodies in seminoma-Associated paraneoplastic encephalitis. / Mandel-brehm, Caleigh; Dubey, Divyanshu; Kryzer, Thomas J.; O'donovan, Brian D.; Tran, Baouyen; Vazquez, Sara E.; Sample, Hannah A.; Zorn, Kelsey C.; Khan, Lillian M.; Bledsoe, Ian O.; Mckeo, Andrew; Pleasure, Samuel J.; Lennon, Vanda A; Derisi, Joseph L.; Wilson, Michael R.; Pittock, Sean J.

In: New England Journal of Medicine, Vol. 381, No. 1, 04.07.2019, p. 47-54.

Research output: Contribution to journalArticle

Mandel-brehm, C, Dubey, D, Kryzer, TJ, O'donovan, BD, Tran, B, Vazquez, SE, Sample, HA, Zorn, KC, Khan, LM, Bledsoe, IO, Mckeo, A, Pleasure, SJ, Lennon, VA, Derisi, JL, Wilson, MR & Pittock, SJ 2019, 'Kelch-like Protein 11 antibodies in seminoma-Associated paraneoplastic encephalitis', New England Journal of Medicine, vol. 381, no. 1, pp. 47-54. https://doi.org/10.1056/NEJMoa1816721
Mandel-brehm, Caleigh ; Dubey, Divyanshu ; Kryzer, Thomas J. ; O'donovan, Brian D. ; Tran, Baouyen ; Vazquez, Sara E. ; Sample, Hannah A. ; Zorn, Kelsey C. ; Khan, Lillian M. ; Bledsoe, Ian O. ; Mckeo, Andrew ; Pleasure, Samuel J. ; Lennon, Vanda A ; Derisi, Joseph L. ; Wilson, Michael R. ; Pittock, Sean J. / Kelch-like Protein 11 antibodies in seminoma-Associated paraneoplastic encephalitis. In: New England Journal of Medicine. 2019 ; Vol. 381, No. 1. pp. 47-54.
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