@article{0307a27cd170469fbab69068d9c9a10b,
title = "Kelch-like Protein 11 antibodies in seminoma-Associated paraneoplastic encephalitis",
abstract = "A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia. An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of programmable phage display. Immunoassays were used to identify KLHL11 IgG in 12 other men with similar neurologic features and testicular disease. Immunostaining of the patient's IgG on mouse brain tissue showed sparse but distinctive points of staining in multiple brain regions, with enrichment in perivascular and perimeningeal tissues. The onset of the neurologic syndrome preceded the diagnosis of seminoma in 9 of the 13 patients. An age-adjusted estimate of the prevalence of autoimmune KLHL11 encephalitis in Olmsted County, Minnesota, was 2.79 cases per 100,000 men.",
author = "Caleigh Mandel-brehm and Divyanshu Dubey and Kryzer, {Thomas J.} and O'donovan, {Brian D.} and Baouyen Tran and Vazquez, {Sara E.} and Sample, {Hannah A.} and Zorn, {Kelsey C.} and Khan, {Lillian M.} and Bledsoe, {Ian O.} and Andrew Mckeo and Pleasure, {Samuel J.} and Lennon, {Vanda A.} and Derisi, {Joseph L.} and Wilson, {Michael R.} and Pittock, {Sean J.}",
note = "Funding Information: Supported by an award (R01AG034676) from the Rochester Epidemiology Project, which is funded by the National Institute on Aging of the National Institutes of Health; a grant (to Dr. DeRisi) from the Chan Zuckerberg Biohub; a grant (to Dr. Wilson) from the Rachleff Foundation; a grant (to Drs. Wilson, DeRisi, and Pleasure) from the University of California, San Francisco, Marcus Program in Precision Medicine Innovation; a grant (to Drs. Wilson, DeRisi, Mandel-Brehm, Pleasure, O{\textquoteright}Donovan, and Tran, Ms. Sample, Ms. Zorn, and Ms. Kahn) from the University of California, San Francisco, Center for Next-Gen Precision Diag- nostics, with funding from the Sandler Foundation and the William K. Bowes, Jr. Foundation; a Mentored Clinical Scientist Development Award (K08NS096117, to Dr. Wilson) from the National Institute of Neurological Disorders and Stroke; and a grant (to Drs. Dubey, McKeon, and Pittock) from the Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic.",
year = "2019",
month = jul,
day = "4",
doi = "10.1056/NEJMoa1816721",
language = "English (US)",
volume = "381",
pages = "47--54",
journal = "New England Journal of Medicine",
issn = "1533-4406",
publisher = "Massachussetts Medical Society",
number = "1",
}