Kaposi varicelliform eruption in patients with Darier disease: A 20-year retrospective study

Kaitlin A. Vogt, Christine M. Lohse, Rokea A. El-Azhary, Lawrence E. Gibson, Julia Lehman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background Kaposi varicelliform eruption (KVE), or herpes simplex virus (HSV) superinfection of pre-existing skin lesions, may complicate Darier disease. Objective We sought to compare the clinical features and outcomes of patients with Darier disease who developed KVE superinfection with those who did not. Methods A 20-year retrospective analysis of 79 patients with Darier disease treated at our institution was performed. Results Eleven (14%) patients developed KVE, of whom 45% required hospitalization for their skin disease during the follow-up period. Patients with KVE had more severe Darier disease (P =.030) and were more likely to be hospitalized (P =.015). HSV was detected in erosions without concomitant vesicles or pustules in 64% of confirmed cases. In all, 23 (55%) patients with erosions had HSV testing pursued. Limitations Retrospective study design is a limitation. Conclusion The majority of KVE occurs in painless or painful erosions that may also appear impetiginized without vesicle or pustule formation. As HSV superinfection is correlated with severe Darier disease and risk for hospitalization, increased recognition of this phenomenon may lead to better patient outcomes.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume72
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Kaposi Varicelliform Eruption
Darier Disease
Retrospective Studies
Simplexvirus
Superinfection
Hospitalization
Skin Diseases
Skin

Keywords

  • Darier disease
  • erosion
  • genodermatoses
  • herpes simplex virus
  • Kaposi varicelliform eruption
  • vesicle

ASJC Scopus subject areas

  • Dermatology

Cite this

Kaposi varicelliform eruption in patients with Darier disease : A 20-year retrospective study. / Vogt, Kaitlin A.; Lohse, Christine M.; El-Azhary, Rokea A.; Gibson, Lawrence E.; Lehman, Julia.

In: Journal of the American Academy of Dermatology, Vol. 72, No. 3, 01.03.2015, p. 481-484.

Research output: Contribution to journalArticle

Vogt, Kaitlin A. ; Lohse, Christine M. ; El-Azhary, Rokea A. ; Gibson, Lawrence E. ; Lehman, Julia. / Kaposi varicelliform eruption in patients with Darier disease : A 20-year retrospective study. In: Journal of the American Academy of Dermatology. 2015 ; Vol. 72, No. 3. pp. 481-484.
@article{446531ba9aa043709de48707a39dfa69,
title = "Kaposi varicelliform eruption in patients with Darier disease: A 20-year retrospective study",
abstract = "Background Kaposi varicelliform eruption (KVE), or herpes simplex virus (HSV) superinfection of pre-existing skin lesions, may complicate Darier disease. Objective We sought to compare the clinical features and outcomes of patients with Darier disease who developed KVE superinfection with those who did not. Methods A 20-year retrospective analysis of 79 patients with Darier disease treated at our institution was performed. Results Eleven (14{\%}) patients developed KVE, of whom 45{\%} required hospitalization for their skin disease during the follow-up period. Patients with KVE had more severe Darier disease (P =.030) and were more likely to be hospitalized (P =.015). HSV was detected in erosions without concomitant vesicles or pustules in 64{\%} of confirmed cases. In all, 23 (55{\%}) patients with erosions had HSV testing pursued. Limitations Retrospective study design is a limitation. Conclusion The majority of KVE occurs in painless or painful erosions that may also appear impetiginized without vesicle or pustule formation. As HSV superinfection is correlated with severe Darier disease and risk for hospitalization, increased recognition of this phenomenon may lead to better patient outcomes.",
keywords = "Darier disease, erosion, genodermatoses, herpes simplex virus, Kaposi varicelliform eruption, vesicle",
author = "Vogt, {Kaitlin A.} and Lohse, {Christine M.} and El-Azhary, {Rokea A.} and Gibson, {Lawrence E.} and Julia Lehman",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.jaad.2014.12.001",
language = "English (US)",
volume = "72",
pages = "481--484",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Kaposi varicelliform eruption in patients with Darier disease

T2 - A 20-year retrospective study

AU - Vogt, Kaitlin A.

AU - Lohse, Christine M.

AU - El-Azhary, Rokea A.

AU - Gibson, Lawrence E.

AU - Lehman, Julia

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background Kaposi varicelliform eruption (KVE), or herpes simplex virus (HSV) superinfection of pre-existing skin lesions, may complicate Darier disease. Objective We sought to compare the clinical features and outcomes of patients with Darier disease who developed KVE superinfection with those who did not. Methods A 20-year retrospective analysis of 79 patients with Darier disease treated at our institution was performed. Results Eleven (14%) patients developed KVE, of whom 45% required hospitalization for their skin disease during the follow-up period. Patients with KVE had more severe Darier disease (P =.030) and were more likely to be hospitalized (P =.015). HSV was detected in erosions without concomitant vesicles or pustules in 64% of confirmed cases. In all, 23 (55%) patients with erosions had HSV testing pursued. Limitations Retrospective study design is a limitation. Conclusion The majority of KVE occurs in painless or painful erosions that may also appear impetiginized without vesicle or pustule formation. As HSV superinfection is correlated with severe Darier disease and risk for hospitalization, increased recognition of this phenomenon may lead to better patient outcomes.

AB - Background Kaposi varicelliform eruption (KVE), or herpes simplex virus (HSV) superinfection of pre-existing skin lesions, may complicate Darier disease. Objective We sought to compare the clinical features and outcomes of patients with Darier disease who developed KVE superinfection with those who did not. Methods A 20-year retrospective analysis of 79 patients with Darier disease treated at our institution was performed. Results Eleven (14%) patients developed KVE, of whom 45% required hospitalization for their skin disease during the follow-up period. Patients with KVE had more severe Darier disease (P =.030) and were more likely to be hospitalized (P =.015). HSV was detected in erosions without concomitant vesicles or pustules in 64% of confirmed cases. In all, 23 (55%) patients with erosions had HSV testing pursued. Limitations Retrospective study design is a limitation. Conclusion The majority of KVE occurs in painless or painful erosions that may also appear impetiginized without vesicle or pustule formation. As HSV superinfection is correlated with severe Darier disease and risk for hospitalization, increased recognition of this phenomenon may lead to better patient outcomes.

KW - Darier disease

KW - erosion

KW - genodermatoses

KW - herpes simplex virus

KW - Kaposi varicelliform eruption

KW - vesicle

UR - http://www.scopus.com/inward/record.url?scp=84925382060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925382060&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2014.12.001

DO - 10.1016/j.jaad.2014.12.001

M3 - Article

C2 - 25582540

AN - SCOPUS:84925382060

VL - 72

SP - 481

EP - 484

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 3

ER -