Joint NCCTG and NABTC prognostic factors analysis for high-grade recurrent glioma

Wenting Wu, Kathleen R. Lamborn, Jan C. Buckner, Paul J. Novotny, Susan M. Chang, Judith R. O'Fallon, Kurt A. Jaeckle, Michael D. Prados

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

The purpose of this study is to determine prognostic factors in patients with high-grade recurrent glioma for 3 outcome variables (overall survival, progression-free survival [PFS], and PFS rate 6 months after study registration [PFS6]). Data from 15 North Central Cancer Treatment Group (NCCTG) trials (n = 469, 1980-2004) and 12 North American Brain Tumor Consortium (NABTC) trials (n = 596, 1998-2002) were included. Eighteen prognostic variables were considered including type of treatment center (community/academic) and initial low-grade histology (yes/no). Recursive partitioning analysis (RPA), Cox proportional hazards, and logistic regression models with bootstrap resampling were used to identify prognostic variables. Longer survival was associated with last known grade (Grade) of III, younger age, ECOG performance score (PS) of 0, shorter time from initial diagnosis (DxTime), and no baseline steroid use. Factors associated with longer PFS were Grade III and shorter DxTime. For patients without temozolomide as part of the treatment regimen, the only factor associated with better PFS6 was Grade III, although DxTime was important in RPA and PS was important in logistic regression. Grade was the most important prognostic factor for all three endpoints regardless of the statistical method used. Other important variables for one or more endpoints included age, PS, and DxTime. Neither type of treatment center nor initial low-grade histology was identified as a major predictor for any endpoint.

Original languageEnglish (US)
Pages (from-to)164-172
Number of pages9
JournalNeuro-oncology
Volume12
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Brain tumors
  • High grade
  • Prognostic factors
  • Recurrent glioma

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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