Abstract
In 1164 cognitively unimpaired persons, aged 50–95 years, from the population-based Mayo Clinic Study of Aging, we examined the relationships of baseline cognition and cognitive changes across the full range of cortical thickness of an Alzheimer signature region of interest and global β-amyloid levels measured by Pittsburgh compound B positron emission tomography (PIB PET) standardized uptake value ratio (SUVR). In machine-learning models accounting for both biomarkers simultaneously, worsening biomarker values were additive and associated with lower baseline global cognition and greater subsequent decline in global cognition. Associations between Alzheimer's disease signature cortical thickness or PIB PET β-amyloid SUVR and baseline cognition were mainly linear. Lower Alzheimer's disease signature cortical thickness values across the entire range of thickness predicted future decline in global cognitive scores, demonstrating its close relationship to cognitive functioning. PIB PET β-amyloid SUVR also predicted cognitive decline across its full range, even when cortical thickness was accounted for. PIB PET β-amyloid's relationship to cognitive decline was nonlinear, more prominent at lower β-amyloid levels and less prominent at higher β-amyloid levels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-131 |
| Number of pages | 11 |
| Journal | Neurobiology of Aging |
| Volume | 65 |
| DOIs | |
| State | Published - May 1 2018 |
Fingerprint
Keywords
- Alzheimer's disease
- Amyloid imaging
- Cognitive aging
- Neurodegeneration biomarkers
- Structural MR imaging
ASJC Scopus subject areas
- Neuroscience(all)
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Joint associations of β-amyloidosis and cortical thickness with cognition. / Knopman, David S; Lundt, Emily S.; Therneau, Terry M; Vemuri, Prashanthi D; Lowe, Val; Kantarci, Kejal M; Gunter, Jeffrey L.; Senjem, Matthew L.; Mielke, Michelle M; Machulda, Mary Margaret; Roberts, Rosebud O; Boeve, Bradley F; Jones, David T; Petersen, Ronald Carl; Jack, Clifford R Jr.
In: Neurobiology of Aging, Vol. 65, 01.05.2018, p. 121-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Joint associations of β-amyloidosis and cortical thickness with cognition
AU - Knopman, David S
AU - Lundt, Emily S.
AU - Therneau, Terry M
AU - Vemuri, Prashanthi D
AU - Lowe, Val
AU - Kantarci, Kejal M
AU - Gunter, Jeffrey L.
AU - Senjem, Matthew L.
AU - Mielke, Michelle M
AU - Machulda, Mary Margaret
AU - Roberts, Rosebud O
AU - Boeve, Bradley F
AU - Jones, David T
AU - Petersen, Ronald Carl
AU - Jack, Clifford R Jr.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - In 1164 cognitively unimpaired persons, aged 50–95 years, from the population-based Mayo Clinic Study of Aging, we examined the relationships of baseline cognition and cognitive changes across the full range of cortical thickness of an Alzheimer signature region of interest and global β-amyloid levels measured by Pittsburgh compound B positron emission tomography (PIB PET) standardized uptake value ratio (SUVR). In machine-learning models accounting for both biomarkers simultaneously, worsening biomarker values were additive and associated with lower baseline global cognition and greater subsequent decline in global cognition. Associations between Alzheimer's disease signature cortical thickness or PIB PET β-amyloid SUVR and baseline cognition were mainly linear. Lower Alzheimer's disease signature cortical thickness values across the entire range of thickness predicted future decline in global cognitive scores, demonstrating its close relationship to cognitive functioning. PIB PET β-amyloid SUVR also predicted cognitive decline across its full range, even when cortical thickness was accounted for. PIB PET β-amyloid's relationship to cognitive decline was nonlinear, more prominent at lower β-amyloid levels and less prominent at higher β-amyloid levels.
AB - In 1164 cognitively unimpaired persons, aged 50–95 years, from the population-based Mayo Clinic Study of Aging, we examined the relationships of baseline cognition and cognitive changes across the full range of cortical thickness of an Alzheimer signature region of interest and global β-amyloid levels measured by Pittsburgh compound B positron emission tomography (PIB PET) standardized uptake value ratio (SUVR). In machine-learning models accounting for both biomarkers simultaneously, worsening biomarker values were additive and associated with lower baseline global cognition and greater subsequent decline in global cognition. Associations between Alzheimer's disease signature cortical thickness or PIB PET β-amyloid SUVR and baseline cognition were mainly linear. Lower Alzheimer's disease signature cortical thickness values across the entire range of thickness predicted future decline in global cognitive scores, demonstrating its close relationship to cognitive functioning. PIB PET β-amyloid SUVR also predicted cognitive decline across its full range, even when cortical thickness was accounted for. PIB PET β-amyloid's relationship to cognitive decline was nonlinear, more prominent at lower β-amyloid levels and less prominent at higher β-amyloid levels.
KW - Alzheimer's disease
KW - Amyloid imaging
KW - Cognitive aging
KW - Neurodegeneration biomarkers
KW - Structural MR imaging
UR - http://www.scopus.com/inward/record.url?scp=85042183759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042183759&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2018.01.017
DO - 10.1016/j.neurobiolaging.2018.01.017
M3 - Article
VL - 65
SP - 121
EP - 131
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -