Jaw claudication in primary systemic amyloidosis

Morie Gertz, R. A. Kyle, W. L. Griffing, G. G. Hunder

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Amyloid deposits in the temporal artery were observed 40 years ago, but the presence of vascular ischemic symptoms in patients with amyloidosis has been infrequently recognized. We examined 22 patients who had typical jaw claudication with biopsy-proven primary amyloidosis. In none was vasculitis a contributing cause of the claudication. However, two patients were misdiagnosed initially as having temporal arteritis and polymyalgia rheumatica and were treated with corticosteroids, which resulted in significant toxicity. Subsequent temporal artery biopsy revealed extensive amyloid deposits in both patients. Jaw claudication was associated with other ischemic vascular symptoms, such as arm or calf claudication. The median survival for the subset of patients with amyloidosis and jaw claudication was 42 months, and that for the entire group of patients with amyloidosis was 12 months. Appropriate staining of temporal artery biopsy specimens is necessary for the correct diagnosis in such cases.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalMedicine
Volume65
Issue number3
StatePublished - 1986

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Jaw
Temporal Arteries
Amyloidosis
Amyloid Plaques
Biopsy
Blood Vessels
Polymyalgia Rheumatica
Giant Cell Arteritis
Vasculitis
Diagnostic Errors
Primary amyloidosis
Adrenal Cortex Hormones
Staining and Labeling
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gertz, M., Kyle, R. A., Griffing, W. L., & Hunder, G. G. (1986). Jaw claudication in primary systemic amyloidosis. Medicine, 65(3), 173-179.

Jaw claudication in primary systemic amyloidosis. / Gertz, Morie; Kyle, R. A.; Griffing, W. L.; Hunder, G. G.

In: Medicine, Vol. 65, No. 3, 1986, p. 173-179.

Research output: Contribution to journalArticle

Gertz, M, Kyle, RA, Griffing, WL & Hunder, GG 1986, 'Jaw claudication in primary systemic amyloidosis', Medicine, vol. 65, no. 3, pp. 173-179.
Gertz M, Kyle RA, Griffing WL, Hunder GG. Jaw claudication in primary systemic amyloidosis. Medicine. 1986;65(3):173-179.
Gertz, Morie ; Kyle, R. A. ; Griffing, W. L. ; Hunder, G. G. / Jaw claudication in primary systemic amyloidosis. In: Medicine. 1986 ; Vol. 65, No. 3. pp. 173-179.
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