Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials

Japanese Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Introduction: We conducted Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) and compared the basic characteristics and progression profiles with those of ADNI in North America. Methods: A total of 537 Japanese subjects with normal cognition, late amnestic mild cognitive impairment (LMCI), or mild Alzheimer's disease (AD) were enrolled using the same criteria as ADNI. Rates of changes in representative cognitive or functional measures were compared for amyloid positron emission tomography- or cerebrospinal fluid amyloid β(1–42)-positive LMCI and mild AD between J-ADNI and ADNI. Results: Amyloid positivity rates were significantly higher in normal cognition of ADNI but at similar levels in LMCI and mild AD between J-ADNI and ADNI. Profiles of decline in cognitive or functional measures in amyloid-positive LMCI in J-ADNI (n = 75) and ADNI (n = 269) were remarkably similar, whereas those in mild AD were milder in J-ADNI (n = 73) compared with ADNI (n = 230). Discussion: These results support the feasibility of bridging of clinical trials in the prodromal stage of AD between Asia and western countries.

Original languageEnglish (US)
Pages (from-to)1077-1087
Number of pages11
JournalAlzheimer's and Dementia
Volume14
Issue number8
DOIs
StatePublished - Aug 2018

Keywords

  • ADNI
  • Alzheimer's disease
  • Amyloid PET imaging
  • Biomarker
  • Harmonization
  • Japan
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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