JAK2V617F and leukemic transformation in myelofibrosis with myeloid metaplasia

Ruben A. Mesa, Heather Powell, Terra Lasho, Gordon DeWald, Rebecca McClure, Ayalew Tefferi

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with myeloid metaplasia (MMM) 72% carried the JAK2V617F mutation. The mutation was observed at expected frequencies in all subtypes of MMM and acute myeloid leukemia. Although the patients with the mutation were younger and had a shorter interval to LT there was no difference in survival. Additionally, both the lack of mutation status progression in serial analysis (available in nine patients) and the low frequency of patients with high mutated allele burden suggest that LT arising from MMM is probably not dependent on changes in JAK2V617F mutation status.

Original languageEnglish (US)
Pages (from-to)1457-1460
Number of pages4
JournalLeukemia Research
Volume30
Issue number11
DOIs
StatePublished - Nov 1 2006

Keywords

  • JAK2(V617F)
  • Leukemic transformation
  • Myelofibrosis with myeloid metaplasia
  • Myeloproliferative disorder

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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