JAK2V617F and leukemic transformation in myelofibrosis with myeloid metaplasia

Ruben A. Mesa; Heather Powell; Terra Lasho; Gordon DeWald; Rebecca McClure; Ayalew Tefferi

doi:10.1016/j.leukres.2006.01.008

JAK2^V617F and leukemic transformation in myelofibrosis with myeloid metaplasia

Ruben A. Mesa, Heather Powell, Terra Lasho, Gordon DeWald, Rebecca McClure, Ayalew Tefferi

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with myeloid metaplasia (MMM) 72% carried the JAK2^V617F mutation. The mutation was observed at expected frequencies in all subtypes of MMM and acute myeloid leukemia. Although the patients with the mutation were younger and had a shorter interval to LT there was no difference in survival. Additionally, both the lack of mutation status progression in serial analysis (available in nine patients) and the low frequency of patients with high mutated allele burden suggest that LT arising from MMM is probably not dependent on changes in JAK2^V617F mutation status.

Original language	English (US)
Pages (from-to)	1457-1460
Number of pages	4
Journal	Leukemia Research
Volume	30
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2006.01.008
State	Published - Nov 2006

Keywords

JAK2(V617F)
Leukemic transformation
Myelofibrosis with myeloid metaplasia
Myeloproliferative disorder

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2006.01.008

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@article{5bb26f52644b4390a981d6fce16c3aba,

title = "JAK2V617F and leukemic transformation in myelofibrosis with myeloid metaplasia",

abstract = "Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with myeloid metaplasia (MMM) 72% carried the JAK2V617F mutation. The mutation was observed at expected frequencies in all subtypes of MMM and acute myeloid leukemia. Although the patients with the mutation were younger and had a shorter interval to LT there was no difference in survival. Additionally, both the lack of mutation status progression in serial analysis (available in nine patients) and the low frequency of patients with high mutated allele burden suggest that LT arising from MMM is probably not dependent on changes in JAK2V617F mutation status.",

keywords = "JAK2(V617F), Leukemic transformation, Myelofibrosis with myeloid metaplasia, Myeloproliferative disorder",

author = "Mesa, {Ruben A.} and Heather Powell and Terra Lasho and Gordon DeWald and Rebecca McClure and Ayalew Tefferi",

note = "Funding Information: This work was supported by 1 K23 CA96780-01 and a grant from the Myeloproliferative Disorders Foundation. There are no financial conflicts of interest to disclose. ",

year = "2006",

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language = "English (US)",

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journal = "Leukemia Research",

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T1 - JAK2V617F and leukemic transformation in myelofibrosis with myeloid metaplasia

AU - Mesa, Ruben A.

AU - Powell, Heather

AU - Lasho, Terra

AU - DeWald, Gordon

AU - McClure, Rebecca

AU - Tefferi, Ayalew

N1 - Funding Information: This work was supported by 1 K23 CA96780-01 and a grant from the Myeloproliferative Disorders Foundation. There are no financial conflicts of interest to disclose.

PY - 2006/11

Y1 - 2006/11

N2 - Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with myeloid metaplasia (MMM) 72% carried the JAK2V617F mutation. The mutation was observed at expected frequencies in all subtypes of MMM and acute myeloid leukemia. Although the patients with the mutation were younger and had a shorter interval to LT there was no difference in survival. Additionally, both the lack of mutation status progression in serial analysis (available in nine patients) and the low frequency of patients with high mutated allele burden suggest that LT arising from MMM is probably not dependent on changes in JAK2V617F mutation status.

AB - Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with myeloid metaplasia (MMM) 72% carried the JAK2V617F mutation. The mutation was observed at expected frequencies in all subtypes of MMM and acute myeloid leukemia. Although the patients with the mutation were younger and had a shorter interval to LT there was no difference in survival. Additionally, both the lack of mutation status progression in serial analysis (available in nine patients) and the low frequency of patients with high mutated allele burden suggest that LT arising from MMM is probably not dependent on changes in JAK2V617F mutation status.

KW - JAK2(V617F)

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KW - Myeloproliferative disorder

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