IVUS detection of vasa vasorum blood flow distribution in coronary artery vessel wall

Regina Moritz; Diane R. Eaker; Jill L. Anderson; Timothy L. Kline; Steven M. Jorgensen; Amir Lerman; Erik L. Ritman

doi:10.1016/j.jcmg.2011.12.027

IVUS detection of vasa vasorum blood flow distribution in coronary artery vessel wall

Regina Moritz, Diane R. Eaker, Jill L. Anderson, Timothy L. Kline, Steven M. Jorgensen, Amir Lerman, Erik L. Ritman

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

There is an increased body of evidence to suggest that the vasa vasorum play a major role in the progression and complications of vulnerable plaque leading to acute coronary syndrome. We propose that detecting changes in the flow in the vascular wall by intravascular ultrasound signals can quantify the presence of vasa vasorum. The results obtained in a porcine model of atherosclerosis suggest that intravascular ultrasound-based estimates of blood flow in the arterial wall can be used in vivo in a clinical research setting to establish the density of vasa vasorum as an indicator of plaque vulnerability.

Original language	English (US)
Pages (from-to)	935-940
Number of pages	6
Journal	JACC: Cardiovascular Imaging
Volume	5
Issue number	9
DOIs	https://doi.org/10.1016/j.jcmg.2011.12.027
State	Published - Sep 2012

Keywords

arterial wall
atherosclerosis
diffusion
embolization
perfusion

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.jcmg.2011.12.027

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title = "IVUS detection of vasa vasorum blood flow distribution in coronary artery vessel wall",

abstract = "There is an increased body of evidence to suggest that the vasa vasorum play a major role in the progression and complications of vulnerable plaque leading to acute coronary syndrome. We propose that detecting changes in the flow in the vascular wall by intravascular ultrasound signals can quantify the presence of vasa vasorum. The results obtained in a porcine model of atherosclerosis suggest that intravascular ultrasound-based estimates of blood flow in the arterial wall can be used in vivo in a clinical research setting to establish the density of vasa vasorum as an indicator of plaque vulnerability.",

keywords = "arterial wall, atherosclerosis, diffusion, embolization, perfusion",

author = "Regina Moritz and Eaker, {Diane R.} and Anderson, {Jill L.} and Kline, {Timothy L.} and Jorgensen, {Steven M.} and Amir Lerman and Ritman, {Erik L.}",

note = "Funding Information: This work was supported in part by National Institutes of Health Grant HL065342 . All authors have reported that they have no relationships relevant to the contents of this paper to disclose. ",

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AU - Moritz, Regina

AU - Eaker, Diane R.

AU - Anderson, Jill L.

AU - Kline, Timothy L.

AU - Jorgensen, Steven M.

AU - Lerman, Amir

AU - Ritman, Erik L.

N1 - Funding Information: This work was supported in part by National Institutes of Health Grant HL065342 . All authors have reported that they have no relationships relevant to the contents of this paper to disclose.

PY - 2012/9

Y1 - 2012/9

N2 - There is an increased body of evidence to suggest that the vasa vasorum play a major role in the progression and complications of vulnerable plaque leading to acute coronary syndrome. We propose that detecting changes in the flow in the vascular wall by intravascular ultrasound signals can quantify the presence of vasa vasorum. The results obtained in a porcine model of atherosclerosis suggest that intravascular ultrasound-based estimates of blood flow in the arterial wall can be used in vivo in a clinical research setting to establish the density of vasa vasorum as an indicator of plaque vulnerability.

AB - There is an increased body of evidence to suggest that the vasa vasorum play a major role in the progression and complications of vulnerable plaque leading to acute coronary syndrome. We propose that detecting changes in the flow in the vascular wall by intravascular ultrasound signals can quantify the presence of vasa vasorum. The results obtained in a porcine model of atherosclerosis suggest that intravascular ultrasound-based estimates of blood flow in the arterial wall can be used in vivo in a clinical research setting to establish the density of vasa vasorum as an indicator of plaque vulnerability.

KW - arterial wall

KW - atherosclerosis

KW - diffusion

KW - embolization

KW - perfusion

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M3 - Review article

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IVUS detection of vasa vasorum blood flow distribution in coronary artery vessel wall

Abstract

Keywords

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