Isometry Invariant Shape Descriptors for Abnormality Detection on Brain Surfaces Affected by Alzheimer's Disease

Yanshuai Tu, Chengfeng Wen, Wen Zhang, Jianfeng Wu, Jie Zhang, Kewei Chen, Richard John Caselli, Eric M. Reiman, Yalin Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alzheimer's disease (AD), a progressive brain disorder, is the most common neurodegenerative disease in older adults. There is a need for brain structural magnetic resonance imaging (MRI) biomarkers to help assess AD progression and intervention effects. Prior research showed that surface based brain imaging features hold great promise as efficient AD biomarkers. However, the complex geometry of cortical surfaces poses a major challenge to defining such a feature that is sensitive in qualification, robust in analysis, and intuitive in visualization. Here we propose a novel isometry invariant shape descriptor for brain morphometry analysis. First, we calculate a global area-preserving mapping from cortical surface to the unit sphere. Based on the mapping, the Beltrami coefficient shape descriptor is calculated. An analysis of average shape descriptors reveals that our detected features are consistent with some previous AD studies where medial temporal lobe volume was identified as an important AD imaging biomarker. We further apply a novel patch-based spherical sparse coding scheme for feature dimension reduction. Later, a support vector machine (SVM) classifier is applied to discriminate 135 amyloid-beta positive persons with the clinical diagnosis of Mild Cognitive Impairment (MCI) from 248 amyloid-beta-negative normal control subjects. The 5-folder cross-validation accuracy is about 81.82\% on the dataset, outperforming some traditional, Freesurfer based, brain surface features. The results show that our shape descriptor is effective in distinguishing dementia due to AD from age-matched normal aging individuals. Our isometry invariant shape descriptors may provide a unique and intuitive way to inspect cortical surface and its morphometry changes.

Original languageEnglish (US)
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages4627-4631
Number of pages5
Volume2018-July
ISBN (Electronic)9781538636466
DOIs
StatePublished - Oct 26 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States
Duration: Jul 18 2018Jul 21 2018

Other

Other40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
CountryUnited States
CityHonolulu
Period7/18/187/21/18

Fingerprint

Brain
Alzheimer Disease
Biomarkers
Imaging techniques
Amyloid
Neurodegenerative diseases
Brain Diseases
Temporal Lobe
Magnetic resonance
Neuroimaging
Neurodegenerative Diseases
Support vector machines
Dementia
Disease Progression
Classifiers
Visualization
Aging of materials
Magnetic Resonance Imaging
Geometry
Research

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Tu, Y., Wen, C., Zhang, W., Wu, J., Zhang, J., Chen, K., ... Wang, Y. (2018). Isometry Invariant Shape Descriptors for Abnormality Detection on Brain Surfaces Affected by Alzheimer's Disease. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (Vol. 2018-July, pp. 4627-4631). [8513129] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8513129

Isometry Invariant Shape Descriptors for Abnormality Detection on Brain Surfaces Affected by Alzheimer's Disease. / Tu, Yanshuai; Wen, Chengfeng; Zhang, Wen; Wu, Jianfeng; Zhang, Jie; Chen, Kewei; Caselli, Richard John; Reiman, Eric M.; Wang, Yalin.

40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Vol. 2018-July Institute of Electrical and Electronics Engineers Inc., 2018. p. 4627-4631 8513129.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tu, Y, Wen, C, Zhang, W, Wu, J, Zhang, J, Chen, K, Caselli, RJ, Reiman, EM & Wang, Y 2018, Isometry Invariant Shape Descriptors for Abnormality Detection on Brain Surfaces Affected by Alzheimer's Disease. in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. vol. 2018-July, 8513129, Institute of Electrical and Electronics Engineers Inc., pp. 4627-4631, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, United States, 7/18/18. https://doi.org/10.1109/EMBC.2018.8513129
Tu Y, Wen C, Zhang W, Wu J, Zhang J, Chen K et al. Isometry Invariant Shape Descriptors for Abnormality Detection on Brain Surfaces Affected by Alzheimer's Disease. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Vol. 2018-July. Institute of Electrical and Electronics Engineers Inc. 2018. p. 4627-4631. 8513129 https://doi.org/10.1109/EMBC.2018.8513129
Tu, Yanshuai ; Wen, Chengfeng ; Zhang, Wen ; Wu, Jianfeng ; Zhang, Jie ; Chen, Kewei ; Caselli, Richard John ; Reiman, Eric M. ; Wang, Yalin. / Isometry Invariant Shape Descriptors for Abnormality Detection on Brain Surfaces Affected by Alzheimer's Disease. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Vol. 2018-July Institute of Electrical and Electronics Engineers Inc., 2018. pp. 4627-4631
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