Isolation of a cDNA encoding the chicken homologue of the human calcium-modulating cyclophilin ligand

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Abstract

In order to identify important regions of the human CAML (calcium-modulating cyclophilin ligand) protein, a cDNA encoding the chicken homologue was isolated using low-stringency hybridization screening of a T-lymphocyte cDNA library. The deduced amino acid sequences of chicken and human CAML show areas of extensive conservation, suggesting an evolutionarily important role in signaling.

Original languageEnglish (US)
Pages (from-to)307-309
Number of pages3
JournalGene
Volume174
Issue number2
DOIs
StatePublished - Jan 1 1996

Keywords

  • CAML
  • Calcineurin
  • Capacitative calcium influx
  • Cyclosporin
  • Immunophilin
  • Signal transduction
  • T-cell activation

ASJC Scopus subject areas

  • Genetics

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