Isolated noncompaction of the left ventricular myocardium in adults: A systematic overview

Nisha L. Bhatia, A. Jamil Tajik, Susan Wilansky, D Eric Steidley, Farouk Mookadam

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Background: Owing to inconsistent diagnostic criteria and small heterogeneous cohorts, little is known about the long-term outcomes of adult left ventricular noncompaction (LVNC), a rare cardiomyopathy with potentially serious outcomes. This systematic overview aimed to better delineate the natural history of adult LVNC. Method and Results: A comprehensive computerized search using "noncompaction" and its synonyms initially identified 206 articles, with reference lists subsequently hand scanned. These searches yielded 5 studies that were eligible for this systematic overview, identifying adult cohorts with isolated LVNC diagnosed by similar echocardiographic criteria. This combined cohort (n = 241) was followed for a mean duration of 39 months. The annualized event rate was 4% for cardiovascular deaths, 6.2% for cardiovascular death and its surrogates (heart transplantation and appropriate implantable cardioverter-defibrillator shocks), and 8.6% for all cardiovascular events (death, stroke, implantable cardioverter-defibrillator shocks, and heart transplantation.) Familial occurrence of LVNC in first-degree relatives was identified by echocardiography in 30% of index cases who were screened. Conclusion: LVNC is an increasingly recognized cardiomyopathy diagnosed by echocardiography and is associated with familial tendencies, arrhythmias, thromboembolism, advanced heart failure, and death.

Original languageEnglish (US)
Pages (from-to)771-778
Number of pages8
JournalJournal of Cardiac Failure
Volume17
Issue number9
DOIs
StatePublished - Sep 2011

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Isolated Noncompaction of the Ventricular Myocardium
Implantable Defibrillators
Heart Transplantation
Cardiomyopathies
Echocardiography
Shock
Thromboembolism
Natural History
Cardiac Arrhythmias
Heart Failure
Hand
Stroke

Keywords

  • arrhythmias
  • Cardiomyopathy
  • heart failure
  • thromboembolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Isolated noncompaction of the left ventricular myocardium in adults : A systematic overview. / Bhatia, Nisha L.; Tajik, A. Jamil; Wilansky, Susan; Steidley, D Eric; Mookadam, Farouk.

In: Journal of Cardiac Failure, Vol. 17, No. 9, 09.2011, p. 771-778.

Research output: Contribution to journalArticle

Bhatia, Nisha L. ; Tajik, A. Jamil ; Wilansky, Susan ; Steidley, D Eric ; Mookadam, Farouk. / Isolated noncompaction of the left ventricular myocardium in adults : A systematic overview. In: Journal of Cardiac Failure. 2011 ; Vol. 17, No. 9. pp. 771-778.
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