Isolated cerebral mucormycosis caused by Rhizomucor pusillus

Saira Farid; Omar Abusaleh; Rachael Liesman; Muhammad Rizwan Sohail

doi:10.1136/bcr-2017-221473

Isolated cerebral mucormycosis caused by Rhizomucor pusillus

Saira Farid, Omar Abusaleh, Rachael Liesman, Muhammad Rizwan Sohail

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A 61-year-old man with relapsing chronic lymphocytic leukaemia, status post allogeneic stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure. His evaluation revealed a 1.5-2 cm ring-enhancing left temporal lobe brain lesion on the CT scan. This brain lesion was resected and the histopathology revealed an invasive fungal organism resembling mucormycosis. Amplification and sequencing of the 28S ribosomal RNA gene identified the organism as Rhizomucor pusillus. The patient was treated with liposomal amphotericin B 5 mg/kg every 24 hours for 4 weeks, and then was transitioned to oral posaconazole. Serial brain imaging at 1 and 3 months, while on therapy, showed significant improvement.

Original language	English (US)
Article number	bcr-2017-221473
Journal	BMJ case reports
Volume	2017
DOIs	https://doi.org/10.1136/bcr-2017-221473
State	Published - 2017

Keywords

infection (neurology)
infectious diseases

ASJC Scopus subject areas

General Medicine

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10.1136/bcr-2017-221473

Cite this

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title = "Isolated cerebral mucormycosis caused by Rhizomucor pusillus",

abstract = "A 61-year-old man with relapsing chronic lymphocytic leukaemia, status post allogeneic stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure. His evaluation revealed a 1.5-2 cm ring-enhancing left temporal lobe brain lesion on the CT scan. This brain lesion was resected and the histopathology revealed an invasive fungal organism resembling mucormycosis. Amplification and sequencing of the 28S ribosomal RNA gene identified the organism as Rhizomucor pusillus. The patient was treated with liposomal amphotericin B 5 mg/kg every 24 hours for 4 weeks, and then was transitioned to oral posaconazole. Serial brain imaging at 1 and 3 months, while on therapy, showed significant improvement.",

keywords = "infection (neurology), infectious diseases",

author = "Saira Farid and Omar Abusaleh and Rachael Liesman and Sohail, {Muhammad Rizwan}",

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T1 - Isolated cerebral mucormycosis caused by Rhizomucor pusillus

AU - Farid, Saira

AU - Abusaleh, Omar

AU - Liesman, Rachael

AU - Sohail, Muhammad Rizwan

PY - 2017

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N2 - A 61-year-old man with relapsing chronic lymphocytic leukaemia, status post allogeneic stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure. His evaluation revealed a 1.5-2 cm ring-enhancing left temporal lobe brain lesion on the CT scan. This brain lesion was resected and the histopathology revealed an invasive fungal organism resembling mucormycosis. Amplification and sequencing of the 28S ribosomal RNA gene identified the organism as Rhizomucor pusillus. The patient was treated with liposomal amphotericin B 5 mg/kg every 24 hours for 4 weeks, and then was transitioned to oral posaconazole. Serial brain imaging at 1 and 3 months, while on therapy, showed significant improvement.

AB - A 61-year-old man with relapsing chronic lymphocytic leukaemia, status post allogeneic stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure. His evaluation revealed a 1.5-2 cm ring-enhancing left temporal lobe brain lesion on the CT scan. This brain lesion was resected and the histopathology revealed an invasive fungal organism resembling mucormycosis. Amplification and sequencing of the 28S ribosomal RNA gene identified the organism as Rhizomucor pusillus. The patient was treated with liposomal amphotericin B 5 mg/kg every 24 hours for 4 weeks, and then was transitioned to oral posaconazole. Serial brain imaging at 1 and 3 months, while on therapy, showed significant improvement.

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Isolated cerebral mucormycosis caused by Rhizomucor pusillus

Abstract

Keywords

ASJC Scopus subject areas

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