Isolated cerebral mucormycosis caused by Rhizomucor pusillus

Saira Farid, Omar Abusaleh, Rachael Liesman, Muhammad Rizwan Sohail

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 61-year-old man with relapsing chronic lymphocytic leukaemia, status post allogeneic stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure. His evaluation revealed a 1.5-2 cm ring-enhancing left temporal lobe brain lesion on the CT scan. This brain lesion was resected and the histopathology revealed an invasive fungal organism resembling mucormycosis. Amplification and sequencing of the 28S ribosomal RNA gene identified the organism as Rhizomucor pusillus. The patient was treated with liposomal amphotericin B 5 mg/kg every 24 hours for 4 weeks, and then was transitioned to oral posaconazole. Serial brain imaging at 1 and 3 months, while on therapy, showed significant improvement.

Original languageEnglish (US)
Article numberbcr-2017-221473
JournalBMJ Case Reports
Volume2017
DOIs
StatePublished - 2017

Fingerprint

Rhizomucor
Mucormycosis
28S Ribosomal RNA
Brain
B-Cell Chronic Lymphocytic Leukemia
Temporal Lobe
rRNA Genes
Neuroimaging
Hospital Emergency Service
Seizures
Stem Cells
Transplants
Drug Therapy
Therapeutics

Keywords

  • infection (neurology)
  • infectious diseases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Farid, S., Abusaleh, O., Liesman, R., & Sohail, M. R. (2017). Isolated cerebral mucormycosis caused by Rhizomucor pusillus. BMJ Case Reports, 2017, [bcr-2017-221473]. https://doi.org/10.1136/bcr-2017-221473

Isolated cerebral mucormycosis caused by Rhizomucor pusillus. / Farid, Saira; Abusaleh, Omar; Liesman, Rachael; Sohail, Muhammad Rizwan.

In: BMJ Case Reports, Vol. 2017, bcr-2017-221473, 2017.

Research output: Contribution to journalArticle

Farid, S, Abusaleh, O, Liesman, R & Sohail, MR 2017, 'Isolated cerebral mucormycosis caused by Rhizomucor pusillus', BMJ Case Reports, vol. 2017, bcr-2017-221473. https://doi.org/10.1136/bcr-2017-221473
Farid, Saira ; Abusaleh, Omar ; Liesman, Rachael ; Sohail, Muhammad Rizwan. / Isolated cerebral mucormycosis caused by Rhizomucor pusillus. In: BMJ Case Reports. 2017 ; Vol. 2017.
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