Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

Julie J. Miller; L. Nicolas Gonzalez Castro; Samuel McBrayer; Michael Weller; Timothy Cloughesy; Jana Portnow; Ovidiu Andronesi; Jill S. Barnholtz-Sloan; Brigitta G. Baumert; Mitchell S. Berger; Wenya Linda Bi; Ranjit Bindra; Daniel P. Cahill; Susan M. Chang; Joseph F. Costello; Craig Horbinski; Raymond Y. Huang; Robert B. Jenkins; Keith L. Ligon; Ingo K. Mellinghoff; L. Burt Nabors; Michael Platten; David A. Reardon; Diana D. Shi; David Schiff; Wolfgang Wick; Hai Yan; Andreas von Deimling; Martin van den Bent; William G. Kaelin; Patrick Y. Wen

doi:10.1093/neuonc/noac207

Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana Portnow, Ovidiu Andronesi, Jill S. Barnholtz-Sloan, Brigitta G. Baumert, Mitchell S. Berger, Wenya Linda Bi, Ranjit Bindra, Daniel P. Cahill, Susan M. Chang, Joseph F. Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. MellinghoffL. Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin van den Bent, William G. Kaelin, Patrick Y. Wen

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant primary brain tumors diagnosed in patients younger than 50, constituting an important cause of morbidity and mortality. In recent years, there has been significant progress in understanding the molecular pathogenesis and biology of these tumors, sparking multiple efforts to improve their diagnosis and treatment. In this consensus review from the Society for Neuro-Oncology (SNO), the current diagnosis and management of IDH-mutant gliomas will be discussed. In addition, novel therapies, such as targeted molecular therapies and immunotherapies, will be reviewed. Current challenges and future directions for research will be discussed.

Original language	English (US)
Pages (from-to)	4-25
Number of pages	22
Journal	Neuro-oncology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1093/neuonc/noac207
State	Published - Jan 5 2023

Keywords

D-2HG
Isocitrate dehydrogenase (IDH)
glioma

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

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10.1093/neuonc/noac207

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Miller, J. J., Gonzalez Castro, L. N., McBrayer, S., Weller, M., Cloughesy, T., Portnow, J., Andronesi, O., Barnholtz-Sloan, J. S., Baumert, B. G., Berger, M. S., Bi, W. L., Bindra, R., Cahill, D. P., Chang, S. M., Costello, J. F., Horbinski, C., Huang, R. Y., Jenkins, R. B., Ligon, K. L., ... Wen, P. Y. (2023). Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. Neuro-oncology, 25(1), 4-25. https://doi.org/10.1093/neuonc/noac207

Miller, JJ, Gonzalez Castro, LN, McBrayer, S, Weller, M, Cloughesy, T, Portnow, J, Andronesi, O, Barnholtz-Sloan, JS, Baumert, BG, Berger, MS, Bi, WL, Bindra, R, Cahill, DP, Chang, SM, Costello, JF, Horbinski, C, Huang, RY, Jenkins, RB, Ligon, KL, Mellinghoff, IK, Nabors, LB, Platten, M, Reardon, DA, Shi, DD, Schiff, D, Wick, W, Yan, H, von Deimling, A, van den Bent, M, Kaelin, WG & Wen, PY 2023, 'Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions', Neuro-oncology, vol. 25, no. 1, pp. 4-25. https://doi.org/10.1093/neuonc/noac207

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title = "Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions",

abstract = "Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant primary brain tumors diagnosed in patients younger than 50, constituting an important cause of morbidity and mortality. In recent years, there has been significant progress in understanding the molecular pathogenesis and biology of these tumors, sparking multiple efforts to improve their diagnosis and treatment. In this consensus review from the Society for Neuro-Oncology (SNO), the current diagnosis and management of IDH-mutant gliomas will be discussed. In addition, novel therapies, such as targeted molecular therapies and immunotherapies, will be reviewed. Current challenges and future directions for research will be discussed.",

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note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",

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AU - McBrayer, Samuel

AU - Weller, Michael

AU - Cloughesy, Timothy

AU - Portnow, Jana

AU - Andronesi, Ovidiu

AU - Barnholtz-Sloan, Jill S.

AU - Baumert, Brigitta G.

AU - Berger, Mitchell S.

AU - Bi, Wenya Linda

AU - Bindra, Ranjit

AU - Cahill, Daniel P.

AU - Chang, Susan M.

AU - Costello, Joseph F.

AU - Horbinski, Craig

AU - Huang, Raymond Y.

AU - Jenkins, Robert B.

AU - Ligon, Keith L.

AU - Mellinghoff, Ingo K.

AU - Nabors, L. Burt

AU - Platten, Michael

AU - Reardon, David A.

AU - Shi, Diana D.

AU - Schiff, David

AU - Wick, Wolfgang

AU - Yan, Hai

AU - von Deimling, Andreas

AU - van den Bent, Martin

AU - Kaelin, William G.

AU - Wen, Patrick Y.

N1 - Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2023/1/5

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N2 - Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant primary brain tumors diagnosed in patients younger than 50, constituting an important cause of morbidity and mortality. In recent years, there has been significant progress in understanding the molecular pathogenesis and biology of these tumors, sparking multiple efforts to improve their diagnosis and treatment. In this consensus review from the Society for Neuro-Oncology (SNO), the current diagnosis and management of IDH-mutant gliomas will be discussed. In addition, novel therapies, such as targeted molecular therapies and immunotherapies, will be reviewed. Current challenges and future directions for research will be discussed.

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Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

Abstract

Keywords

ASJC Scopus subject areas

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