Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour

Kristiina Heinonen; P. Nagesh Rao; James L. Slack; Julia Cruz; Clara D. Bloomfield; Krzysztof Mrózek

doi:10.1046/j.1365-2141.1996.d01-1687.x

Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour

Kristiina Heinonen, P. Nagesh Rao, James L. Slack, Julia Cruz, Clara D. Bloomfield, Krzysztof Mrózek

Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

An isochromosome 12P [i(12p)], typical of germ cell tumours (GCT), has, to date, been observed in 10 cases of acute myeloid leukaemia (AML) or myelodysplastic syndrome, nine of which had concurrent or preceding GCT, We report two i(12p)-positive AML cases without clinical evidence of GCT, One patient with AML-M1 had two i(12p) as the only cytogenetic anomalies. In the other case of AML-M3 with t(15;17)(q22;q11-12) at diagnosis, the i(12p) was clearly a secondary rearrangement since it first appeared at relapse and always accompanied the t(15;17). Our results suggest that i(12p) does not always indicate neoplastic disease of germ cell origin.

Original language	English (US)
Pages (from-to)	677-680
Number of pages	4
Journal	British journal of haematology
Volume	93
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2141.1996.d01-1687.x
State	Published - 1996

Keywords

AML
Germ cell tumour
Isochromosome 12p
Karyotyping

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.1996.d01-1687.x

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title = "Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour",

abstract = "An isochromosome 12P [i(12p)], typical of germ cell tumours (GCT), has, to date, been observed in 10 cases of acute myeloid leukaemia (AML) or myelodysplastic syndrome, nine of which had concurrent or preceding GCT, We report two i(12p)-positive AML cases without clinical evidence of GCT, One patient with AML-M1 had two i(12p) as the only cytogenetic anomalies. In the other case of AML-M3 with t(15;17)(q22;q11-12) at diagnosis, the i(12p) was clearly a secondary rearrangement since it first appeared at relapse and always accompanied the t(15;17). Our results suggest that i(12p) does not always indicate neoplastic disease of germ cell origin.",

keywords = "AML, Germ cell tumour, Isochromosome 12p, Karyotyping",

author = "Kristiina Heinonen and Rao, {P. Nagesh} and Slack, {James L.} and Julia Cruz and Bloomfield, {Clara D.} and Krzysztof Mr{\'o}zek",

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T1 - Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour

AU - Heinonen, Kristiina

AU - Rao, P. Nagesh

AU - Slack, James L.

AU - Cruz, Julia

AU - Bloomfield, Clara D.

AU - Mrózek, Krzysztof

PY - 1996

Y1 - 1996

N2 - An isochromosome 12P [i(12p)], typical of germ cell tumours (GCT), has, to date, been observed in 10 cases of acute myeloid leukaemia (AML) or myelodysplastic syndrome, nine of which had concurrent or preceding GCT, We report two i(12p)-positive AML cases without clinical evidence of GCT, One patient with AML-M1 had two i(12p) as the only cytogenetic anomalies. In the other case of AML-M3 with t(15;17)(q22;q11-12) at diagnosis, the i(12p) was clearly a secondary rearrangement since it first appeared at relapse and always accompanied the t(15;17). Our results suggest that i(12p) does not always indicate neoplastic disease of germ cell origin.

AB - An isochromosome 12P [i(12p)], typical of germ cell tumours (GCT), has, to date, been observed in 10 cases of acute myeloid leukaemia (AML) or myelodysplastic syndrome, nine of which had concurrent or preceding GCT, We report two i(12p)-positive AML cases without clinical evidence of GCT, One patient with AML-M1 had two i(12p) as the only cytogenetic anomalies. In the other case of AML-M3 with t(15;17)(q22;q11-12) at diagnosis, the i(12p) was clearly a secondary rearrangement since it first appeared at relapse and always accompanied the t(15;17). Our results suggest that i(12p) does not always indicate neoplastic disease of germ cell origin.

KW - AML

KW - Germ cell tumour

KW - Isochromosome 12p

KW - Karyotyping

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ER -

Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour

Abstract

Keywords

ASJC Scopus subject areas

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