Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour

Kristiina Heinonen, P. Nagesh Rao, James L. Slack, Julia Cruz, Clara D. Bloomfield, Krzysztof Mrózek

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

An isochromosome 12P [i(12p)], typical of germ cell tumours (GCT), has, to date, been observed in 10 cases of acute myeloid leukaemia (AML) or myelodysplastic syndrome, nine of which had concurrent or preceding GCT, We report two i(12p)-positive AML cases without clinical evidence of GCT, One patient with AML-M1 had two i(12p) as the only cytogenetic anomalies. In the other case of AML-M3 with t(15;17)(q22;q11-12) at diagnosis, the i(12p) was clearly a secondary rearrangement since it first appeared at relapse and always accompanied the t(15;17). Our results suggest that i(12p) does not always indicate neoplastic disease of germ cell origin.

Original languageEnglish (US)
Pages (from-to)677-680
Number of pages4
JournalBritish journal of haematology
Volume93
Issue number3
DOIs
StatePublished - 1996

Keywords

  • AML
  • Germ cell tumour
  • Isochromosome 12p
  • Karyotyping

ASJC Scopus subject areas

  • Hematology

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