Islet amyloidosis in a patient with chronic massive insulin resistance due to antiinsulin receptor antibodies

Timothy D. O’brien, Robert A. Rizza, J. Aid An Carney, Peter C. Butler

Research output: Contribution to journalArticle

17 Scopus citations


We report islet hyperplasia, nesidioblastosis, and abundant islet amyloidosis (derived from islet amyloid polypeptide) in a case of severe insulin resistance due to a circulating antiinsulin receptor antibody. Massive chronic β-cell stimulation (as well as noninsulin-dependent diabetes mellitus and insulinoma) appears to be associated with islet amyloid.

Original languageEnglish (US)
Pages (from-to)290-292
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number1
StatePublished - 1994


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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