Ischemic stroke: Update on prevention part 2, the role of statins and antiplatelet agents

Kevin M. Barrett, Karen C. Johnston

Research output: Contribution to journalArticlepeer-review


Statins reduce stroke risk in patients with coronary artery disease (CAD); a recent study demonstrated that statins are also effective in patients with previous stroke or transient ischemic attack who do not have CAD. In patients with peripheral artery disease, antiplatelet therapy with clopidogrel is more effective than aspirin therapy. However, in other patient populations, the choice of an antiplatelet agent can be based on cost and side-effect profiles. Combination therapy with dopidogrel and aspirin is recommended only for patients who have a cardiac indication for such therapy and for those in whom a stent has recently been placed. If, despite risk factor modification and antiplatelet therapy, a patient has recurrent stroke, it is important to reevaluate for both common and less common stroke mechanisms and to modify preventive strategies accordingly.

Original languageEnglish (US)
Pages (from-to)615-619
Number of pages5
Issue number8
StatePublished - Jul 2008


  • Carotid angioplasty
  • Carotid endarterectomy
  • Ischemic stroke
  • Secondary prevention
  • Stenting

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Ischemic stroke: Update on prevention part 2, the role of statins and antiplatelet agents'. Together they form a unique fingerprint.

Cite this