TY - JOUR
T1 - Ischemic Stroke Risk in Patients With Nonvalvular Atrial Fibrillation
T2 - JACC Review Topic of the Week
AU - Alkhouli, Mohamad
AU - Friedman, Paul A.
N1 - Publisher Copyright:
© 2019 American College of Cardiology Foundation
PY - 2019/12/17
Y1 - 2019/12/17
N2 - The last decade has witnessed remarkable advances in pharmacological and nonpharmacological strategies for stroke prevention in patients with atrial fibrillation. However, the currently available clinical stroke risk prediction models do not account for key nonclinical factors (arrhythmia burden, left atrial physiology and anatomy, chemical and electrocardiographic markers) and other competing clinical risks. Hence, their ability to identify patients who will derive the most benefit from pharmacological and mechanical risk prevention strategies remain limited. In this paper, the authors review the current and evolving ischemic stroke risk prediction schemes in patients with nonvalvular atrial fibrillation, highlight the strengths and weaknesses of the models, and discuss the unmet needs in this field.
AB - The last decade has witnessed remarkable advances in pharmacological and nonpharmacological strategies for stroke prevention in patients with atrial fibrillation. However, the currently available clinical stroke risk prediction models do not account for key nonclinical factors (arrhythmia burden, left atrial physiology and anatomy, chemical and electrocardiographic markers) and other competing clinical risks. Hence, their ability to identify patients who will derive the most benefit from pharmacological and mechanical risk prevention strategies remain limited. In this paper, the authors review the current and evolving ischemic stroke risk prediction schemes in patients with nonvalvular atrial fibrillation, highlight the strengths and weaknesses of the models, and discuss the unmet needs in this field.
KW - atrial fibrillation
KW - oral anticoagulation
KW - risk assessment
KW - stroke
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U2 - 10.1016/j.jacc.2019.10.040
DO - 10.1016/j.jacc.2019.10.040
M3 - Review article
C2 - 31865973
AN - SCOPUS:85075584790
SN - 0735-1097
VL - 74
SP - 3050
EP - 3065
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 24
ER -