Is total body irradiation a necessary component of preparative therapy for autologous transplantation in non-Hodgkin's lymphoma

R. S. Stein, J. P. Greer, S. Goodman, S. J. Brandt, D. S. Morgan, W. R. Macon, T. L. McCurley, S. N. Wolff

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Between September 1986 and June 1998, 157 patients with low grade, intermediate grade, or high grade lymphoma underwent autologous transplantation at a single institution. Two preparative regimens were used: cyclophosphamide, etoposide, total body irradiation (CY-VP-TBI) (N=110) and cyclophosphamide, BCNU, etoposide (CBV) (N=47). The two groups were not significantly different with respect to source of stem cells, gender, stage at presentation, incidence of prior bone marrow involvement, sensitivity to salvage therapy, or histologic grade of lymphoma. The CBV group was significantly older, 49% of patients over age 50, as compared to 26% of patients over age 50 for the CY-VP-TBI group. Response rates and the incidence of fatal toxicity were similar for the two groups. Five year actuarial survival was 31% ±9% for CBV and 38%± 5% for CY-VP-TBI, p=.85. In a multivariate analysis, in which preparative regimen, age, histologic grade of lymphoma, and sensitivity to salvage therapy were the independent variables, TBI was not significantly associated with survival, and the direction of the trend was for TBI to be less effective than CBV. TBI does not appear to be an essential component of preparative therapy for autologous transplantation in patients with lymphoma.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalLeukemia and Lymphoma
Volume41
Issue number1-2
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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