Is There a Role for Desmopressin in Liver Transplantation? A Case Report

M. M. Gonzales; D. Z. Valdes; R. Helmick; T. Taner; G. Vasdev

doi:10.1016/j.transproceed.2015.09.044

Is There a Role for Desmopressin in Liver Transplantation? A Case Report

M. M. Gonzales, D. Z. Valdes, R. Helmick, T. Taner, G. Vasdev

Transplant Surgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Living donor liver transplantation reduces time and mortality on the waiting list. Bleeding is a serious complication; however, "overcorrection" of coagulopathy may lead to hepatic artery thrombosis. We report a case where desmopressin (DDAVP) was used in the management of persistent postreperfusion bleeding (44 red blood cell units transfused). After 1 dose of DDAVP, bleeding improved significantly and the recipient had an unremarkable recovery. DDAVP should be considered for persisting bleeding after correcting common coagulation abnormalities where complexity of the anastomosis may preclude the use of more aggressive procoagulant drugs in liver transplantation.

Original language	English (US)
Pages (from-to)	2782-2785
Number of pages	4
Journal	Transplantation proceedings
Volume	47
Issue number	9
DOIs	https://doi.org/10.1016/j.transproceed.2015.09.044
State	Published - Nov 1 2015

ASJC Scopus subject areas

Surgery
Transplantation

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10.1016/j.transproceed.2015.09.044

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AU - Vasdev, G.

PY - 2015/11/1

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AB - Living donor liver transplantation reduces time and mortality on the waiting list. Bleeding is a serious complication; however, "overcorrection" of coagulopathy may lead to hepatic artery thrombosis. We report a case where desmopressin (DDAVP) was used in the management of persistent postreperfusion bleeding (44 red blood cell units transfused). After 1 dose of DDAVP, bleeding improved significantly and the recipient had an unremarkable recovery. DDAVP should be considered for persisting bleeding after correcting common coagulation abnormalities where complexity of the anastomosis may preclude the use of more aggressive procoagulant drugs in liver transplantation.

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Is There a Role for Desmopressin in Liver Transplantation? A Case Report

Abstract

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