Is the serum vitamin D-parathyroid hormone relationship influenced by obesity in children?

Z. Amini, S. Bryant, C. Smith, Ravinder Jit Singh, S. Kumar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background/Aims: Serum 25 hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) levels correlate inversely. The 25(OH)D level at which PTH is maximally suppressed and below which PTH begins to rise (inflection point) has been used to define optimum 25(OH)D levels. While serum 25(OH)D levels are lower in obese individuals, likely due to sequestration of vitamin D in the adipose tissue, it is not known if the lower 25(OH)D levels in obese children are associated with a PTH increase in the same manner as it is in normal weight children. Methods: A retrospective record review of children between 2 and 18 years of age (n = 269) undergoing simultaneous measurement of serum 25(OH)D and PTH levels was performed. Results: The level of serum 25(OH)D below which PTH begins to rise was significantly lower (p < 0.001) in overweight/obese children compared to normal weight children [12.4 (95% CI 9.8-15.0) vs. 17.0 ng/ml (95% CI 11.4-22.6)]. Conclusions: In overweight and obese children, the PTH axis is activated at much lower 25(OH)D levels than in normal weight children. These findings are a consequence of similar ionized calcium levels in these groups despite lower serum 25(OH)D levels in obese children.

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalHormone Research in Paediatrics
Volume80
Issue number4
DOIs
StatePublished - Oct 2013

Fingerprint

Pediatric Obesity
Parathyroid Hormone
Vitamin D
Serum
Weights and Measures
Adipose Tissue
Calcium

Keywords

  • 25-Hydroxyvitamin D
  • Childhood obesity
  • Inflection point
  • Obesity
  • Parathyroid hormone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Is the serum vitamin D-parathyroid hormone relationship influenced by obesity in children? / Amini, Z.; Bryant, S.; Smith, C.; Singh, Ravinder Jit; Kumar, S.

In: Hormone Research in Paediatrics, Vol. 80, No. 4, 10.2013, p. 252-256.

Research output: Contribution to journalArticle

@article{a9c4c29f32b74ad396a959160263b0da,
title = "Is the serum vitamin D-parathyroid hormone relationship influenced by obesity in children?",
abstract = "Background/Aims: Serum 25 hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) levels correlate inversely. The 25(OH)D level at which PTH is maximally suppressed and below which PTH begins to rise (inflection point) has been used to define optimum 25(OH)D levels. While serum 25(OH)D levels are lower in obese individuals, likely due to sequestration of vitamin D in the adipose tissue, it is not known if the lower 25(OH)D levels in obese children are associated with a PTH increase in the same manner as it is in normal weight children. Methods: A retrospective record review of children between 2 and 18 years of age (n = 269) undergoing simultaneous measurement of serum 25(OH)D and PTH levels was performed. Results: The level of serum 25(OH)D below which PTH begins to rise was significantly lower (p < 0.001) in overweight/obese children compared to normal weight children [12.4 (95{\%} CI 9.8-15.0) vs. 17.0 ng/ml (95{\%} CI 11.4-22.6)]. Conclusions: In overweight and obese children, the PTH axis is activated at much lower 25(OH)D levels than in normal weight children. These findings are a consequence of similar ionized calcium levels in these groups despite lower serum 25(OH)D levels in obese children.",
keywords = "25-Hydroxyvitamin D, Childhood obesity, Inflection point, Obesity, Parathyroid hormone",
author = "Z. Amini and S. Bryant and C. Smith and Singh, {Ravinder Jit} and S. Kumar",
year = "2013",
month = "10",
doi = "10.1159/000354645",
language = "English (US)",
volume = "80",
pages = "252--256",
journal = "Hormone Research in Paediatrics",
issn = "1663-2818",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Is the serum vitamin D-parathyroid hormone relationship influenced by obesity in children?

AU - Amini, Z.

AU - Bryant, S.

AU - Smith, C.

AU - Singh, Ravinder Jit

AU - Kumar, S.

PY - 2013/10

Y1 - 2013/10

N2 - Background/Aims: Serum 25 hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) levels correlate inversely. The 25(OH)D level at which PTH is maximally suppressed and below which PTH begins to rise (inflection point) has been used to define optimum 25(OH)D levels. While serum 25(OH)D levels are lower in obese individuals, likely due to sequestration of vitamin D in the adipose tissue, it is not known if the lower 25(OH)D levels in obese children are associated with a PTH increase in the same manner as it is in normal weight children. Methods: A retrospective record review of children between 2 and 18 years of age (n = 269) undergoing simultaneous measurement of serum 25(OH)D and PTH levels was performed. Results: The level of serum 25(OH)D below which PTH begins to rise was significantly lower (p < 0.001) in overweight/obese children compared to normal weight children [12.4 (95% CI 9.8-15.0) vs. 17.0 ng/ml (95% CI 11.4-22.6)]. Conclusions: In overweight and obese children, the PTH axis is activated at much lower 25(OH)D levels than in normal weight children. These findings are a consequence of similar ionized calcium levels in these groups despite lower serum 25(OH)D levels in obese children.

AB - Background/Aims: Serum 25 hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) levels correlate inversely. The 25(OH)D level at which PTH is maximally suppressed and below which PTH begins to rise (inflection point) has been used to define optimum 25(OH)D levels. While serum 25(OH)D levels are lower in obese individuals, likely due to sequestration of vitamin D in the adipose tissue, it is not known if the lower 25(OH)D levels in obese children are associated with a PTH increase in the same manner as it is in normal weight children. Methods: A retrospective record review of children between 2 and 18 years of age (n = 269) undergoing simultaneous measurement of serum 25(OH)D and PTH levels was performed. Results: The level of serum 25(OH)D below which PTH begins to rise was significantly lower (p < 0.001) in overweight/obese children compared to normal weight children [12.4 (95% CI 9.8-15.0) vs. 17.0 ng/ml (95% CI 11.4-22.6)]. Conclusions: In overweight and obese children, the PTH axis is activated at much lower 25(OH)D levels than in normal weight children. These findings are a consequence of similar ionized calcium levels in these groups despite lower serum 25(OH)D levels in obese children.

KW - 25-Hydroxyvitamin D

KW - Childhood obesity

KW - Inflection point

KW - Obesity

KW - Parathyroid hormone

UR - http://www.scopus.com/inward/record.url?scp=84888250847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888250847&partnerID=8YFLogxK

U2 - 10.1159/000354645

DO - 10.1159/000354645

M3 - Article

C2 - 24080758

AN - SCOPUS:84888250847

VL - 80

SP - 252

EP - 256

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

SN - 1663-2818

IS - 4

ER -