Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion?

R. Ramhorst, E. Agriello, S. Zittermann, M. Pando, J. Larriba, L. Fainboim, M. Irigoyen, J. J. Etchepareborda, C. Contreras Ortiz, M. Cortelezzi, L. Auge, E. Lombardi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Problem: Alloimmunization as a treatment for recurrent spontaneous abortion (RSA) is still controversial due to the lack of enough controls to evaluate its effectiveness. The present study was conducted to compare the live birth rate in the presence or absence of immunotherapy. Method of study: Ninety-two women with RSA (79 primary [PA] and 13 secondary aborters[SA]) received immunotherapy. Thirty-seven RSA couples not receiving paternal alloimmunization, constituted the 'control' group. Results: The pregnancy rate in alloimmunized was 58 vs 46% in the control group. The live birth increased from 71% in the controls to 88% after immunotherapy. The alloimmunization induced mixed lymphocyte reaction blocking factors (MLR BFs) in 79% of women. However, they were also present in 83% of immunized women experiencing a new abortion. Conclusion: These results indicate that alloimmunization may be useful in the treatment of RSA.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume44
Issue number3
StatePublished - 2000
Externally publishedYes

Fingerprint

Habitual Abortion
Spontaneous Abortion
Immunization
Immunotherapy
Live Birth
Control Groups
Mixed Lymphocyte Culture Test
Birth Rate
Pregnancy Rate
Therapeutics

Keywords

  • Alloimmunization
  • HLA
  • Recurrent spontaneous abortion

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynecology

Cite this

Ramhorst, R., Agriello, E., Zittermann, S., Pando, M., Larriba, J., Fainboim, L., ... Lombardi, E. (2000). Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion? American Journal of Reproductive Immunology, 44(3), 129-135.

Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion? / Ramhorst, R.; Agriello, E.; Zittermann, S.; Pando, M.; Larriba, J.; Fainboim, L.; Irigoyen, M.; Etchepareborda, J. J.; Contreras Ortiz, C.; Cortelezzi, M.; Auge, L.; Lombardi, E.

In: American Journal of Reproductive Immunology, Vol. 44, No. 3, 2000, p. 129-135.

Research output: Contribution to journalArticle

Ramhorst, R, Agriello, E, Zittermann, S, Pando, M, Larriba, J, Fainboim, L, Irigoyen, M, Etchepareborda, JJ, Contreras Ortiz, C, Cortelezzi, M, Auge, L & Lombardi, E 2000, 'Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion?', American Journal of Reproductive Immunology, vol. 44, no. 3, pp. 129-135.
Ramhorst, R. ; Agriello, E. ; Zittermann, S. ; Pando, M. ; Larriba, J. ; Fainboim, L. ; Irigoyen, M. ; Etchepareborda, J. J. ; Contreras Ortiz, C. ; Cortelezzi, M. ; Auge, L. ; Lombardi, E. / Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion?. In: American Journal of Reproductive Immunology. 2000 ; Vol. 44, No. 3. pp. 129-135.
@article{cee9ed9c6ed749e78dcdeb3388eb2e6b,
title = "Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion?",
abstract = "Problem: Alloimmunization as a treatment for recurrent spontaneous abortion (RSA) is still controversial due to the lack of enough controls to evaluate its effectiveness. The present study was conducted to compare the live birth rate in the presence or absence of immunotherapy. Method of study: Ninety-two women with RSA (79 primary [PA] and 13 secondary aborters[SA]) received immunotherapy. Thirty-seven RSA couples not receiving paternal alloimmunization, constituted the 'control' group. Results: The pregnancy rate in alloimmunized was 58 vs 46{\%} in the control group. The live birth increased from 71{\%} in the controls to 88{\%} after immunotherapy. The alloimmunization induced mixed lymphocyte reaction blocking factors (MLR BFs) in 79{\%} of women. However, they were also present in 83{\%} of immunized women experiencing a new abortion. Conclusion: These results indicate that alloimmunization may be useful in the treatment of RSA.",
keywords = "Alloimmunization, HLA, Recurrent spontaneous abortion",
author = "R. Ramhorst and E. Agriello and S. Zittermann and M. Pando and J. Larriba and L. Fainboim and M. Irigoyen and Etchepareborda, {J. J.} and {Contreras Ortiz}, C. and M. Cortelezzi and L. Auge and E. Lombardi",
year = "2000",
language = "English (US)",
volume = "44",
pages = "129--135",
journal = "American Journal of Reproductive Immunology",
issn = "1046-7408",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion?

AU - Ramhorst, R.

AU - Agriello, E.

AU - Zittermann, S.

AU - Pando, M.

AU - Larriba, J.

AU - Fainboim, L.

AU - Irigoyen, M.

AU - Etchepareborda, J. J.

AU - Contreras Ortiz, C.

AU - Cortelezzi, M.

AU - Auge, L.

AU - Lombardi, E.

PY - 2000

Y1 - 2000

N2 - Problem: Alloimmunization as a treatment for recurrent spontaneous abortion (RSA) is still controversial due to the lack of enough controls to evaluate its effectiveness. The present study was conducted to compare the live birth rate in the presence or absence of immunotherapy. Method of study: Ninety-two women with RSA (79 primary [PA] and 13 secondary aborters[SA]) received immunotherapy. Thirty-seven RSA couples not receiving paternal alloimmunization, constituted the 'control' group. Results: The pregnancy rate in alloimmunized was 58 vs 46% in the control group. The live birth increased from 71% in the controls to 88% after immunotherapy. The alloimmunization induced mixed lymphocyte reaction blocking factors (MLR BFs) in 79% of women. However, they were also present in 83% of immunized women experiencing a new abortion. Conclusion: These results indicate that alloimmunization may be useful in the treatment of RSA.

AB - Problem: Alloimmunization as a treatment for recurrent spontaneous abortion (RSA) is still controversial due to the lack of enough controls to evaluate its effectiveness. The present study was conducted to compare the live birth rate in the presence or absence of immunotherapy. Method of study: Ninety-two women with RSA (79 primary [PA] and 13 secondary aborters[SA]) received immunotherapy. Thirty-seven RSA couples not receiving paternal alloimmunization, constituted the 'control' group. Results: The pregnancy rate in alloimmunized was 58 vs 46% in the control group. The live birth increased from 71% in the controls to 88% after immunotherapy. The alloimmunization induced mixed lymphocyte reaction blocking factors (MLR BFs) in 79% of women. However, they were also present in 83% of immunized women experiencing a new abortion. Conclusion: These results indicate that alloimmunization may be useful in the treatment of RSA.

KW - Alloimmunization

KW - HLA

KW - Recurrent spontaneous abortion

UR - http://www.scopus.com/inward/record.url?scp=0033865823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033865823&partnerID=8YFLogxK

M3 - Article

C2 - 11028898

AN - SCOPUS:0033865823

VL - 44

SP - 129

EP - 135

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

SN - 1046-7408

IS - 3

ER -