Is the neuropathological 'gold standard' diagnosis dead? Implications of clinicopathological findings in an autosomal dominant neurodegenerative disorder

Ryan J. Uitti, Donald B. Calne, Dennis W Dickson, Zbigniew K Wszolek

Research output: Contribution to journalArticle

17 Scopus citations


Genetically-derived neurodegenerative disorders offer a rare opportunity to test validity of neuropathological criteria for diagnosis. Implications regarding an autosomal dominant neurodegenerative disorder (PARK 8) in which four different neuropathological diagnoses were found at autopsy are discussed. We suggest that just as there is currently no clinical 'gold standard' for Parkinson's disease, there is no pathological 'gold standard.' We conclude that in certain circumstances genetic studies may provide definitive arbitration of validity of clinical and pathological diagnostic criteria.

Original languageEnglish (US)
Pages (from-to)461-463
Number of pages3
JournalParkinsonism and Related Disorders
Issue number8
StatePublished - Dec 2004



  • Diagnosis
  • Neuropathology
  • PARK 8
  • Parkinsonism

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

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