Is the functional decline of Parkinson's disease similar to the functional decline of Alzheimer's disease?

M. N. Sabbagh; N. Silverberg; S. Bircea; B. Majeed; S. Samant; J. N. Caviness; B. Reisberg; C. H. Adler

doi:10.1016/j.parkreldis.2005.02.004

Is the functional decline of Parkinson's disease similar to the functional decline of Alzheimer's disease?

M. N. Sabbagh, N. Silverberg, S. Bircea, B. Majeed, S. Samant, J. N. Caviness, B. Reisberg, C. H. Adler

Neurology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Since many Parkinson's disease (PD) subjects develop dementia, we determined whether the correlation between functional and cognitive decline seen in Alzheimer's disease (AD) is seen in PD. Seventy-five PD subjects with and without dementia and 103 AD/MCI subjects underwent the Functional Assessment Staging (FAST), the Global Deterioration Scale (GDS), the UPDRS motor portion, and the MMSE. In AD/MCI subjects, changes in FAST and GDS scores correlated with MMSE (ρ=-0.814, P<0.001; ρ=-0.840, P<0.001, respectively). In PD subjects, the FAST and GDS also correlated with MMSE (ρ=-0.675, P<0.001; ρ=-0.647, P<0.001, respectively). The UPDRS correlated with the GDS and FAST more closely in PD than in AD. Similar to AD, functional declines in PD correlates with cognitive decline and may be influenced by motor disability in PD.

Original language	English (US)
Pages (from-to)	311-315
Number of pages	5
Journal	Parkinsonism and Related Disorders
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.parkreldis.2005.02.004
State	Published - Aug 2005

Keywords

Alzheimer's
Cognitive decline
Function
Parkinson's

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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@article{bf02af9402f3413dac1b9f5332438bea,

title = "Is the functional decline of Parkinson's disease similar to the functional decline of Alzheimer's disease?",

abstract = "Since many Parkinson's disease (PD) subjects develop dementia, we determined whether the correlation between functional and cognitive decline seen in Alzheimer's disease (AD) is seen in PD. Seventy-five PD subjects with and without dementia and 103 AD/MCI subjects underwent the Functional Assessment Staging (FAST), the Global Deterioration Scale (GDS), the UPDRS motor portion, and the MMSE. In AD/MCI subjects, changes in FAST and GDS scores correlated with MMSE (ρ=-0.814, P<0.001; ρ=-0.840, P<0.001, respectively). In PD subjects, the FAST and GDS also correlated with MMSE (ρ=-0.675, P<0.001; ρ=-0.647, P<0.001, respectively). The UPDRS correlated with the GDS and FAST more closely in PD than in AD. Similar to AD, functional declines in PD correlates with cognitive decline and may be influenced by motor disability in PD.",

keywords = "Alzheimer's, Cognitive decline, Function, Parkinson's",

author = "Sabbagh, {M. N.} and N. Silverberg and S. Bircea and B. Majeed and S. Samant and Caviness, {J. N.} and B. Reisberg and Adler, {C. H.}",

note = "Funding Information: Supported by AG 019610, AG 08051, the Sun Health Research Institute, NS40699, Arizona Disease Control Research Commission contract 4001 to Arizona Parkinson's Disease Center.",

year = "2005",

month = aug,

doi = "10.1016/j.parkreldis.2005.02.004",

language = "English (US)",

volume = "11",

pages = "311--315",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",