Is multiple sclerosis an autoimmune disease?

Bharath Wootla, Makoto Eriguchi, Moses Rodriguez

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with varied clinical presentations and heterogeneous histopathological features. The underlying immunological abnormalities in MS lead to various neurological and autoimmune manifestations. There is strong evidence that MS is, at least in part, an immune-mediated disease. There is less evidence that MS is a classical autoimmune disease, even though many authors state this in the description of the disease. We show the evidence that both supports and refutes the autoimmune hypothesis. In addition, we present an alternate hypothesis based on virus infection to explain the pathogenesis of MS.

Original languageEnglish (US)
Article number969657
JournalAutoimmune Diseases
Issue number1
StatePublished - 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Immunology and Microbiology (miscellaneous)


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