Is hormone replacement a risk factor for ischemic stroke in women with factor V Leiden mutation?

James F Meschia, José Biller, Thomas Witt, Anne Greist, Steve N. Rhinehart

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To describe a patient with multifocal cerebral ischemia whose only identified potential risk factors were use of postmenopausal hormone replacement and heterozygosity to factor V Leiden mutation. Design: A case report. Setting: A tertiary care center. Patient: A 51-year-old woman taking hormone replacement (0.625 mg/d of estrogen alternating with 10 mg/d of medroxyprogesterone) presented with a generalized tonic-clonic seizure. She had persistent multifocal nonenhancing lesions on magnetic resonance imaging of the brain. A stereotactic biopsy of the brain performed to exclude gliomatosis cerebri was consistent with cerebral ischemia. An extensive evaluation to uncover the cause of stroke revealed only heterozygosity to factor V Leiden mutation. Main-Outcome and Results: Hormonal replacement was discontinued and the patient had no recurrent ischemic strokes. Conclusions: Postmenopausal hormonal replacement may be a risk factor for ischemic stroke in women with the factor V Leiden mutation. Ongoing trials of hormonal replacement provide an opportunity to test this hypothesis.

Original languageEnglish (US)
Pages (from-to)1137-1139
Number of pages3
JournalArchives of Neurology
Volume55
Issue number8
DOIs
StatePublished - Aug 1998

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Stroke
Hormones
Brain Ischemia
Mutation
Medroxyprogesterone
Neuroepithelial Neoplasms
Brain
Tertiary Care Centers
Estrogens
Seizures
Magnetic Resonance Imaging
Biopsy
factor V Leiden
Replacement
Risk Factors
Leiden

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Is hormone replacement a risk factor for ischemic stroke in women with factor V Leiden mutation? / Meschia, James F; Biller, José; Witt, Thomas; Greist, Anne; Rhinehart, Steve N.

In: Archives of Neurology, Vol. 55, No. 8, 08.1998, p. 1137-1139.

Research output: Contribution to journalArticle

Meschia, James F ; Biller, José ; Witt, Thomas ; Greist, Anne ; Rhinehart, Steve N. / Is hormone replacement a risk factor for ischemic stroke in women with factor V Leiden mutation?. In: Archives of Neurology. 1998 ; Vol. 55, No. 8. pp. 1137-1139.
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