TY - JOUR
T1 - Is exposure to famine in childhood and economic development in adulthood associated with diabetes?
AU - Wang, Ningjian
AU - Wang, Xiaojin
AU - Han, Bing
AU - Li, Qin
AU - Chen, Yi
AU - Zhu, Chunfang
AU - Chen, Yingchao
AU - Xia, Fangzhen
AU - Cang, Zhen
AU - Zhu, Chaoxia
AU - Lu, Meng
AU - Meng, Ying
AU - Chen, Chi
AU - Lin, Dongping
AU - Wang, Bingshun
AU - Jensen, Michael D.
AU - Lu, Yingli
N1 - Publisher Copyright:
Copyright © 2015 by the Endocrine Society.
PY - 2015/12
Y1 - 2015/12
N2 - Context: The Chinese were afflicted by great famine between 1959 and 1962. These people then experienced rapid economic development during which the gross domestic product per capita increased from $28 in 1978 to $6807 in 2013. We hypothesize that these two events are associated with the booming rate of diabetes in China. Objective:Weaimed to explore whether exposure to famine in early life and high economic status in adulthood was associated with diabetes in later life. Design and Setting: Our data of 6897 adults were from across-sectional Survey on Prevalence in East China for Metabolic Diseases and Risk Factors study in 2014. Among them, 3844 adults experienced famine during different life stages and then lived in areas with different economic statuses in adulthood. Main Outcome Measure: Diabetes was considered as fasting plasma glucose of 7.0mmol/L or greater, hemoglobin A1c of 6.5% or greater, and/or a previous diagnosis by health care professionals. Results: Compared with nonexposed subjects, famine exposure during the fetal period (odds ratio [OR]1.53, 95% confidence interval [CI]1.09 -2.14) and childhood (OR 1.82, 95% CI 1.21-2.73) was associated with diabetes after adjusting for age and gender. Further adjustments for adiposity, height, the lipid profile, and blood pressure did not significantly attenuate this association. Subjects living in areas with high economic status had a greater diabetes risk in adulthood (OR 1.46, 95%CI 1.20-1.78). In gender-specific analyses, fetal-exposed men (OR 1.64,95%CI, 1.04-2.59) and childhood-exposed women (OR 2.81, 95% CI, 1.59-4.97) had significantly greater risk of diabetes. Conclusions: The rapid increase in the prevalence of diabetes in middle-aged and elderly people in China is associated with the combination of exposure to famine during the fetal stage and childhood and high economic status in adulthood. Our findings may partly explain the booming diabetes phenomenon in China.
AB - Context: The Chinese were afflicted by great famine between 1959 and 1962. These people then experienced rapid economic development during which the gross domestic product per capita increased from $28 in 1978 to $6807 in 2013. We hypothesize that these two events are associated with the booming rate of diabetes in China. Objective:Weaimed to explore whether exposure to famine in early life and high economic status in adulthood was associated with diabetes in later life. Design and Setting: Our data of 6897 adults were from across-sectional Survey on Prevalence in East China for Metabolic Diseases and Risk Factors study in 2014. Among them, 3844 adults experienced famine during different life stages and then lived in areas with different economic statuses in adulthood. Main Outcome Measure: Diabetes was considered as fasting plasma glucose of 7.0mmol/L or greater, hemoglobin A1c of 6.5% or greater, and/or a previous diagnosis by health care professionals. Results: Compared with nonexposed subjects, famine exposure during the fetal period (odds ratio [OR]1.53, 95% confidence interval [CI]1.09 -2.14) and childhood (OR 1.82, 95% CI 1.21-2.73) was associated with diabetes after adjusting for age and gender. Further adjustments for adiposity, height, the lipid profile, and blood pressure did not significantly attenuate this association. Subjects living in areas with high economic status had a greater diabetes risk in adulthood (OR 1.46, 95%CI 1.20-1.78). In gender-specific analyses, fetal-exposed men (OR 1.64,95%CI, 1.04-2.59) and childhood-exposed women (OR 2.81, 95% CI, 1.59-4.97) had significantly greater risk of diabetes. Conclusions: The rapid increase in the prevalence of diabetes in middle-aged and elderly people in China is associated with the combination of exposure to famine during the fetal stage and childhood and high economic status in adulthood. Our findings may partly explain the booming diabetes phenomenon in China.
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U2 - 10.1210/jc.2015-2750
DO - 10.1210/jc.2015-2750
M3 - Article
C2 - 26509871
AN - SCOPUS:84951077040
SN - 0021-972X
VL - 100
SP - 4514
EP - 4523
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 12
ER -