Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast?

Bryan Mulheron, Richard J. Gray, Barbara A Pockaj, Heidi Apsey

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The value of excisional biopsy for patients with lobular neoplasia diagnosed by core needle breast biopsy is controversial. Methods: A retrospective analysis of all patients with lobular carcinoma in situ or atypical lobular hyperplasia on core needle biopsy. Results: Twenty-five patients were identified. Twelve (48%) underwent excisional biopsy. None of the patients who had excisional biopsy were found to have ductal carcinoma in situ (DCIS) or invasive cancer. The mean follow-up was 66 months. Five patients (20%) developed DCIS or invasive cancer during follow-up. The rate of subsequent carcinoma among those undergoing excisional biopsy was 25%, and among those not undergoing excisional biopsy it was 15% (P = .57). Among patients who did not undergo excisional biopsy, none developed carcinoma within the same quadrant of the breast. Conclusions: Excisional biopsy for lobular neoplasia did not identify understaged carcinoma or alter the rate of subsequent carcinoma. The subsequent carcinoma risk is diffuse and bilateral; it does not correlate with the site at which lobular neoplasia was diagnosed.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalAmerican Journal of Surgery
Volume198
Issue number6
DOIs
StatePublished - Dec 2009

Fingerprint

Large-Core Needle Biopsy
Breast
Biopsy
Carcinoma
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Hyperplasia

Keywords

  • Atypical lobular hyperplasia
  • Breast
  • Core needle biopsy
  • Excisional biopsy
  • Lobular carcinoma in-situ
  • Percutaneous biopsy

ASJC Scopus subject areas

  • Surgery

Cite this

Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast? / Mulheron, Bryan; Gray, Richard J.; Pockaj, Barbara A; Apsey, Heidi.

In: American Journal of Surgery, Vol. 198, No. 6, 12.2009, p. 792-797.

Research output: Contribution to journalArticle

@article{e6826f7c83654d2992c9bb77e9bf26d5,
title = "Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast?",
abstract = "Background: The value of excisional biopsy for patients with lobular neoplasia diagnosed by core needle breast biopsy is controversial. Methods: A retrospective analysis of all patients with lobular carcinoma in situ or atypical lobular hyperplasia on core needle biopsy. Results: Twenty-five patients were identified. Twelve (48{\%}) underwent excisional biopsy. None of the patients who had excisional biopsy were found to have ductal carcinoma in situ (DCIS) or invasive cancer. The mean follow-up was 66 months. Five patients (20{\%}) developed DCIS or invasive cancer during follow-up. The rate of subsequent carcinoma among those undergoing excisional biopsy was 25{\%}, and among those not undergoing excisional biopsy it was 15{\%} (P = .57). Among patients who did not undergo excisional biopsy, none developed carcinoma within the same quadrant of the breast. Conclusions: Excisional biopsy for lobular neoplasia did not identify understaged carcinoma or alter the rate of subsequent carcinoma. The subsequent carcinoma risk is diffuse and bilateral; it does not correlate with the site at which lobular neoplasia was diagnosed.",
keywords = "Atypical lobular hyperplasia, Breast, Core needle biopsy, Excisional biopsy, Lobular carcinoma in-situ, Percutaneous biopsy",
author = "Bryan Mulheron and Gray, {Richard J.} and Pockaj, {Barbara A} and Heidi Apsey",
year = "2009",
month = "12",
doi = "10.1016/j.amjsurg.2009.04.026",
language = "English (US)",
volume = "198",
pages = "792--797",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast?

AU - Mulheron, Bryan

AU - Gray, Richard J.

AU - Pockaj, Barbara A

AU - Apsey, Heidi

PY - 2009/12

Y1 - 2009/12

N2 - Background: The value of excisional biopsy for patients with lobular neoplasia diagnosed by core needle breast biopsy is controversial. Methods: A retrospective analysis of all patients with lobular carcinoma in situ or atypical lobular hyperplasia on core needle biopsy. Results: Twenty-five patients were identified. Twelve (48%) underwent excisional biopsy. None of the patients who had excisional biopsy were found to have ductal carcinoma in situ (DCIS) or invasive cancer. The mean follow-up was 66 months. Five patients (20%) developed DCIS or invasive cancer during follow-up. The rate of subsequent carcinoma among those undergoing excisional biopsy was 25%, and among those not undergoing excisional biopsy it was 15% (P = .57). Among patients who did not undergo excisional biopsy, none developed carcinoma within the same quadrant of the breast. Conclusions: Excisional biopsy for lobular neoplasia did not identify understaged carcinoma or alter the rate of subsequent carcinoma. The subsequent carcinoma risk is diffuse and bilateral; it does not correlate with the site at which lobular neoplasia was diagnosed.

AB - Background: The value of excisional biopsy for patients with lobular neoplasia diagnosed by core needle breast biopsy is controversial. Methods: A retrospective analysis of all patients with lobular carcinoma in situ or atypical lobular hyperplasia on core needle biopsy. Results: Twenty-five patients were identified. Twelve (48%) underwent excisional biopsy. None of the patients who had excisional biopsy were found to have ductal carcinoma in situ (DCIS) or invasive cancer. The mean follow-up was 66 months. Five patients (20%) developed DCIS or invasive cancer during follow-up. The rate of subsequent carcinoma among those undergoing excisional biopsy was 25%, and among those not undergoing excisional biopsy it was 15% (P = .57). Among patients who did not undergo excisional biopsy, none developed carcinoma within the same quadrant of the breast. Conclusions: Excisional biopsy for lobular neoplasia did not identify understaged carcinoma or alter the rate of subsequent carcinoma. The subsequent carcinoma risk is diffuse and bilateral; it does not correlate with the site at which lobular neoplasia was diagnosed.

KW - Atypical lobular hyperplasia

KW - Breast

KW - Core needle biopsy

KW - Excisional biopsy

KW - Lobular carcinoma in-situ

KW - Percutaneous biopsy

UR - http://www.scopus.com/inward/record.url?scp=71149119811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71149119811&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2009.04.026

DO - 10.1016/j.amjsurg.2009.04.026

M3 - Article

C2 - 19969131

AN - SCOPUS:71149119811

VL - 198

SP - 792

EP - 797

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 6

ER -