Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?

Marianna Karachaliou, Silvia de Sanjose, Tim Waterboer, Theano Roumeliotaki, Maria Vassilaki, Katerina Sarri, Vasiliki Leventakou, Marina Vafeiadi, Georgia Chalkiadaki, Eftichia Stiakaki, Angelika Michel, Michael Pawlita, Manolis Kogevinas, Leda Chatzi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. Methods: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4. Body mass index, waist circumference, and skinfold thickness were measured at age 4 and 6. Data on serum lipids, leptin, and adiponectin were also available. Multivariable linear regression models were used to explore the associations. Results: At 4 years of age, seroprevalence to polyomaviruses ranged from 21.0% for HPyV9 to 82.0% for HPyV10. Seroprevalence for EBV, CMV, HSV-1, and HSV-2 was 53.0%, 26.0%, 3.6%, and 1.5% respectively. BKPyV seropositivity was associated with lower BMI SD score at age 4 [−0.21 (95% CI: −0.39, −0.03)] and 6 [−0.27 (95% CI:-0.48, −0.05)], waist circumference at age 4 [−1.12 cm (95% CI: −2.10, −0.15)] and 6 [−1.73 cm (95% CI: −3.33, −0.12)], sum of four skinfolds [−2.97 mm (95% CI: −5.70, −0.24)], and leptin levels at age 4 [ratio of geometric means, 0.83 (95% CI: 0.70, 0.98)]. CMV seropositivity was associated with higher BMI SD score at age 4 [0.28 (95% CI: 0.11, 0.45)] and 6 [0.24 (95% CI: 0.03, 0.45)] and sum of four skinfolds at age 6 [4.75 mm (95% CI: 0.67, 8.83)]. Having “2–3 herpesviruses infections” (versus “0 herpesvirus infections”) was associated with higher BMI SD score [0.32, (95% CI: 0.12, 0.53)], waist circumference [1.22 cm (95% CI: 0.13, 2.31)], and sum of four skinfolds [3.26 mm (95% CI: 0.18, 6.35)] at age 4. Polyomaviruses burden was not associated with outcomes. Conclusions: A higher herpesviruses burden and CMV seropositivity were associated with obesity traits in childhood.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalInternational Journal of Obesity
DOIs
StateAccepted/In press - Jan 30 2018

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Polyomavirus
Herpesviridae
Waist Circumference
Herpesviridae Infections
Human Herpesvirus 2
Obesity
Seroepidemiologic Studies
Human Herpesvirus 1
Leptin
Human Herpesvirus 4
Linear Models
Rheiformes
Skinfold Thickness
Pediatric Obesity
Adiponectin
Body Mass Index
Immunoglobulin G
Parturition
Viruses
Lipids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood? / Karachaliou, Marianna; de Sanjose, Silvia; Waterboer, Tim; Roumeliotaki, Theano; Vassilaki, Maria; Sarri, Katerina; Leventakou, Vasiliki; Vafeiadi, Marina; Chalkiadaki, Georgia; Stiakaki, Eftichia; Michel, Angelika; Pawlita, Michael; Kogevinas, Manolis; Chatzi, Leda.

In: International Journal of Obesity, 30.01.2018, p. 1-12.

Research output: Contribution to journalArticle

Karachaliou, M, de Sanjose, S, Waterboer, T, Roumeliotaki, T, Vassilaki, M, Sarri, K, Leventakou, V, Vafeiadi, M, Chalkiadaki, G, Stiakaki, E, Michel, A, Pawlita, M, Kogevinas, M & Chatzi, L 2018, 'Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?', International Journal of Obesity, pp. 1-12. https://doi.org/10.1038/s41366-018-0017-1
Karachaliou, Marianna ; de Sanjose, Silvia ; Waterboer, Tim ; Roumeliotaki, Theano ; Vassilaki, Maria ; Sarri, Katerina ; Leventakou, Vasiliki ; Vafeiadi, Marina ; Chalkiadaki, Georgia ; Stiakaki, Eftichia ; Michel, Angelika ; Pawlita, Michael ; Kogevinas, Manolis ; Chatzi, Leda. / Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?. In: International Journal of Obesity. 2018 ; pp. 1-12.
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title = "Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?",
abstract = "Background: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. Methods: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4. Body mass index, waist circumference, and skinfold thickness were measured at age 4 and 6. Data on serum lipids, leptin, and adiponectin were also available. Multivariable linear regression models were used to explore the associations. Results: At 4 years of age, seroprevalence to polyomaviruses ranged from 21.0{\%} for HPyV9 to 82.0{\%} for HPyV10. Seroprevalence for EBV, CMV, HSV-1, and HSV-2 was 53.0{\%}, 26.0{\%}, 3.6{\%}, and 1.5{\%} respectively. BKPyV seropositivity was associated with lower BMI SD score at age 4 [−0.21 (95{\%} CI: −0.39, −0.03)] and 6 [−0.27 (95{\%} CI:-0.48, −0.05)], waist circumference at age 4 [−1.12 cm (95{\%} CI: −2.10, −0.15)] and 6 [−1.73 cm (95{\%} CI: −3.33, −0.12)], sum of four skinfolds [−2.97 mm (95{\%} CI: −5.70, −0.24)], and leptin levels at age 4 [ratio of geometric means, 0.83 (95{\%} CI: 0.70, 0.98)]. CMV seropositivity was associated with higher BMI SD score at age 4 [0.28 (95{\%} CI: 0.11, 0.45)] and 6 [0.24 (95{\%} CI: 0.03, 0.45)] and sum of four skinfolds at age 6 [4.75 mm (95{\%} CI: 0.67, 8.83)]. Having “2–3 herpesviruses infections” (versus “0 herpesvirus infections”) was associated with higher BMI SD score [0.32, (95{\%} CI: 0.12, 0.53)], waist circumference [1.22 cm (95{\%} CI: 0.13, 2.31)], and sum of four skinfolds [3.26 mm (95{\%} CI: 0.18, 6.35)] at age 4. Polyomaviruses burden was not associated with outcomes. Conclusions: A higher herpesviruses burden and CMV seropositivity were associated with obesity traits in childhood.",
author = "Marianna Karachaliou and {de Sanjose}, Silvia and Tim Waterboer and Theano Roumeliotaki and Maria Vassilaki and Katerina Sarri and Vasiliki Leventakou and Marina Vafeiadi and Georgia Chalkiadaki and Eftichia Stiakaki and Angelika Michel and Michael Pawlita and Manolis Kogevinas and Leda Chatzi",
year = "2018",
month = "1",
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doi = "10.1038/s41366-018-0017-1",
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journal = "International Journal of Obesity",
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TY - JOUR

T1 - Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?

AU - Karachaliou, Marianna

AU - de Sanjose, Silvia

AU - Waterboer, Tim

AU - Roumeliotaki, Theano

AU - Vassilaki, Maria

AU - Sarri, Katerina

AU - Leventakou, Vasiliki

AU - Vafeiadi, Marina

AU - Chalkiadaki, Georgia

AU - Stiakaki, Eftichia

AU - Michel, Angelika

AU - Pawlita, Michael

AU - Kogevinas, Manolis

AU - Chatzi, Leda

PY - 2018/1/30

Y1 - 2018/1/30

N2 - Background: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. Methods: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4. Body mass index, waist circumference, and skinfold thickness were measured at age 4 and 6. Data on serum lipids, leptin, and adiponectin were also available. Multivariable linear regression models were used to explore the associations. Results: At 4 years of age, seroprevalence to polyomaviruses ranged from 21.0% for HPyV9 to 82.0% for HPyV10. Seroprevalence for EBV, CMV, HSV-1, and HSV-2 was 53.0%, 26.0%, 3.6%, and 1.5% respectively. BKPyV seropositivity was associated with lower BMI SD score at age 4 [−0.21 (95% CI: −0.39, −0.03)] and 6 [−0.27 (95% CI:-0.48, −0.05)], waist circumference at age 4 [−1.12 cm (95% CI: −2.10, −0.15)] and 6 [−1.73 cm (95% CI: −3.33, −0.12)], sum of four skinfolds [−2.97 mm (95% CI: −5.70, −0.24)], and leptin levels at age 4 [ratio of geometric means, 0.83 (95% CI: 0.70, 0.98)]. CMV seropositivity was associated with higher BMI SD score at age 4 [0.28 (95% CI: 0.11, 0.45)] and 6 [0.24 (95% CI: 0.03, 0.45)] and sum of four skinfolds at age 6 [4.75 mm (95% CI: 0.67, 8.83)]. Having “2–3 herpesviruses infections” (versus “0 herpesvirus infections”) was associated with higher BMI SD score [0.32, (95% CI: 0.12, 0.53)], waist circumference [1.22 cm (95% CI: 0.13, 2.31)], and sum of four skinfolds [3.26 mm (95% CI: 0.18, 6.35)] at age 4. Polyomaviruses burden was not associated with outcomes. Conclusions: A higher herpesviruses burden and CMV seropositivity were associated with obesity traits in childhood.

AB - Background: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. Methods: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4. Body mass index, waist circumference, and skinfold thickness were measured at age 4 and 6. Data on serum lipids, leptin, and adiponectin were also available. Multivariable linear regression models were used to explore the associations. Results: At 4 years of age, seroprevalence to polyomaviruses ranged from 21.0% for HPyV9 to 82.0% for HPyV10. Seroprevalence for EBV, CMV, HSV-1, and HSV-2 was 53.0%, 26.0%, 3.6%, and 1.5% respectively. BKPyV seropositivity was associated with lower BMI SD score at age 4 [−0.21 (95% CI: −0.39, −0.03)] and 6 [−0.27 (95% CI:-0.48, −0.05)], waist circumference at age 4 [−1.12 cm (95% CI: −2.10, −0.15)] and 6 [−1.73 cm (95% CI: −3.33, −0.12)], sum of four skinfolds [−2.97 mm (95% CI: −5.70, −0.24)], and leptin levels at age 4 [ratio of geometric means, 0.83 (95% CI: 0.70, 0.98)]. CMV seropositivity was associated with higher BMI SD score at age 4 [0.28 (95% CI: 0.11, 0.45)] and 6 [0.24 (95% CI: 0.03, 0.45)] and sum of four skinfolds at age 6 [4.75 mm (95% CI: 0.67, 8.83)]. Having “2–3 herpesviruses infections” (versus “0 herpesvirus infections”) was associated with higher BMI SD score [0.32, (95% CI: 0.12, 0.53)], waist circumference [1.22 cm (95% CI: 0.13, 2.31)], and sum of four skinfolds [3.26 mm (95% CI: 0.18, 6.35)] at age 4. Polyomaviruses burden was not associated with outcomes. Conclusions: A higher herpesviruses burden and CMV seropositivity were associated with obesity traits in childhood.

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