TY - JOUR
T1 - Is digoxin a drug of the past? This old drug is still useful, with some caveats
AU - Pervaiz, Mohammad Hassan
AU - Dickinson, Michael G.
AU - Yamani, Mohamad
PY - 2006/9
Y1 - 2006/9
N2 - Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.
AB - Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.
UR - http://www.scopus.com/inward/record.url?scp=33748642161&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748642161&partnerID=8YFLogxK
U2 - 10.3949/ccjm.73.9.821
DO - 10.3949/ccjm.73.9.821
M3 - Article
C2 - 16970134
AN - SCOPUS:33748642161
SN - 0891-1150
VL - 73
SP - 821
EP - 834
JO - Cleveland Clinic Journal of Medicine
JF - Cleveland Clinic Journal of Medicine
IS - 9
ER -