Is digoxin a drug of the past? This old drug is still useful, with some caveats

Mohammad Hassan Pervaiz, Michael G. Dickinson, Mohamad Yamani

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.

Original languageEnglish (US)
Pages (from-to)821-834
Number of pages14
JournalCleveland Clinic Journal of Medicine
Volume73
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Digoxin
Heart Failure
Treatment Failure
Pharmaceutical Preparations
Pharmacologic Actions
Mortality
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Is digoxin a drug of the past? This old drug is still useful, with some caveats. / Pervaiz, Mohammad Hassan; Dickinson, Michael G.; Yamani, Mohamad.

In: Cleveland Clinic Journal of Medicine, Vol. 73, No. 9, 09.2006, p. 821-834.

Research output: Contribution to journalArticle

Pervaiz, Mohammad Hassan ; Dickinson, Michael G. ; Yamani, Mohamad. / Is digoxin a drug of the past? This old drug is still useful, with some caveats. In: Cleveland Clinic Journal of Medicine. 2006 ; Vol. 73, No. 9. pp. 821-834.
@article{fbba62745be94d4ea0f8d077828838c3,
title = "Is digoxin a drug of the past? This old drug is still useful, with some caveats",
abstract = "Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.",
author = "Pervaiz, {Mohammad Hassan} and Dickinson, {Michael G.} and Mohamad Yamani",
year = "2006",
month = "9",
doi = "10.3949/ccjm.73.9.821",
language = "English (US)",
volume = "73",
pages = "821--834",
journal = "Cleveland Clinic Journal of Medicine",
issn = "0891-1150",
publisher = "Cleveland Clinic Educational Foundation",
number = "9",

}

TY - JOUR

T1 - Is digoxin a drug of the past? This old drug is still useful, with some caveats

AU - Pervaiz, Mohammad Hassan

AU - Dickinson, Michael G.

AU - Yamani, Mohamad

PY - 2006/9

Y1 - 2006/9

N2 - Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.

AB - Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.

UR - http://www.scopus.com/inward/record.url?scp=33748642161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748642161&partnerID=8YFLogxK

U2 - 10.3949/ccjm.73.9.821

DO - 10.3949/ccjm.73.9.821

M3 - Article

VL - 73

SP - 821

EP - 834

JO - Cleveland Clinic Journal of Medicine

JF - Cleveland Clinic Journal of Medicine

SN - 0891-1150

IS - 9

ER -