Is diabetes mellitus an independent risk factor for venous thromboembolism? A population-based case-control study

John A. Heit, Cynthia L. Leibson, Aneel Arjun Ashrani, Tanya M. Petterson, Kent R Bailey, L. Joseph Melton

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

OBJECTIVE-: Although diabetes mellitus is reported as a risk factor for venous thromboembolism (VTE), persons with diabetes are frequently hospitalized for medical illness or surgery, or confined to a nursing home, all major VTE risk factors. Consequently, we tested diabetes for an independent association with incident VTE. METHODS AND RESULTS-: Using Rochester Epidemiology Project resources, we identified all Olmsted County, Minn residents who met objective criteria for incident VTE over the 25-year period, 1976 to 2000 (n=1922), and 1 to 2 resident controls per case, matched on age, gender, and length of medical history (n=2115). Complete medical histories in the community were reviewed for previously identified independent VTE risk factors and diabetes-related variables. We tested diabetes and diabetes complications (retinopathy, nephropathy or neuropathy, and ketoacidosis) as potential VTE risk factors, both alone and after adjusting for VTE risk factors. Univariately, diabetes by clinical diagnosis or by stricter criteria (fasting ambulatory blood glucose ≥140 mg/dL or antidiabetic drug therapy), and diabetes complications, were associated with overall incident VTE. However, after controlling for hospitalization for major surgery or medical illness and nursing home confinement, diabetes was no longer associated with VTE. CONCLUSION-: Diabetes mellitus and diabetes complications are not independent risk factors for incident VTE.

Original languageEnglish (US)
Pages (from-to)1399-1405
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume29
Issue number9
DOIs
StatePublished - Sep 2009

Fingerprint

Venous Thromboembolism
Case-Control Studies
Diabetes Mellitus
Population
Diabetes Complications
Nursing Homes
Patient-Centered Care
Ketosis
Hypoglycemic Agents
Blood Glucose
Fasting
Epidemiology
Hospitalization
Drug Therapy

Keywords

  • Deep vein thrombosis
  • Diabetes mellitus
  • Pulmonary embolism
  • Venous thromboembolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Is diabetes mellitus an independent risk factor for venous thromboembolism? A population-based case-control study. / Heit, John A.; Leibson, Cynthia L.; Ashrani, Aneel Arjun; Petterson, Tanya M.; Bailey, Kent R; Melton, L. Joseph.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 29, No. 9, 09.2009, p. 1399-1405.

Research output: Contribution to journalArticle

@article{642236fa71c64b2bb5c74cbd2b5e9894,
title = "Is diabetes mellitus an independent risk factor for venous thromboembolism?: A population-based case-control study",
abstract = "OBJECTIVE-: Although diabetes mellitus is reported as a risk factor for venous thromboembolism (VTE), persons with diabetes are frequently hospitalized for medical illness or surgery, or confined to a nursing home, all major VTE risk factors. Consequently, we tested diabetes for an independent association with incident VTE. METHODS AND RESULTS-: Using Rochester Epidemiology Project resources, we identified all Olmsted County, Minn residents who met objective criteria for incident VTE over the 25-year period, 1976 to 2000 (n=1922), and 1 to 2 resident controls per case, matched on age, gender, and length of medical history (n=2115). Complete medical histories in the community were reviewed for previously identified independent VTE risk factors and diabetes-related variables. We tested diabetes and diabetes complications (retinopathy, nephropathy or neuropathy, and ketoacidosis) as potential VTE risk factors, both alone and after adjusting for VTE risk factors. Univariately, diabetes by clinical diagnosis or by stricter criteria (fasting ambulatory blood glucose ≥140 mg/dL or antidiabetic drug therapy), and diabetes complications, were associated with overall incident VTE. However, after controlling for hospitalization for major surgery or medical illness and nursing home confinement, diabetes was no longer associated with VTE. CONCLUSION-: Diabetes mellitus and diabetes complications are not independent risk factors for incident VTE.",
keywords = "Deep vein thrombosis, Diabetes mellitus, Pulmonary embolism, Venous thromboembolism",
author = "Heit, {John A.} and Leibson, {Cynthia L.} and Ashrani, {Aneel Arjun} and Petterson, {Tanya M.} and Bailey, {Kent R} and Melton, {L. Joseph}",
year = "2009",
month = "9",
doi = "10.1161/ATVBAHA.109.189290",
language = "English (US)",
volume = "29",
pages = "1399--1405",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Is diabetes mellitus an independent risk factor for venous thromboembolism?

T2 - A population-based case-control study

AU - Heit, John A.

AU - Leibson, Cynthia L.

AU - Ashrani, Aneel Arjun

AU - Petterson, Tanya M.

AU - Bailey, Kent R

AU - Melton, L. Joseph

PY - 2009/9

Y1 - 2009/9

N2 - OBJECTIVE-: Although diabetes mellitus is reported as a risk factor for venous thromboembolism (VTE), persons with diabetes are frequently hospitalized for medical illness or surgery, or confined to a nursing home, all major VTE risk factors. Consequently, we tested diabetes for an independent association with incident VTE. METHODS AND RESULTS-: Using Rochester Epidemiology Project resources, we identified all Olmsted County, Minn residents who met objective criteria for incident VTE over the 25-year period, 1976 to 2000 (n=1922), and 1 to 2 resident controls per case, matched on age, gender, and length of medical history (n=2115). Complete medical histories in the community were reviewed for previously identified independent VTE risk factors and diabetes-related variables. We tested diabetes and diabetes complications (retinopathy, nephropathy or neuropathy, and ketoacidosis) as potential VTE risk factors, both alone and after adjusting for VTE risk factors. Univariately, diabetes by clinical diagnosis or by stricter criteria (fasting ambulatory blood glucose ≥140 mg/dL or antidiabetic drug therapy), and diabetes complications, were associated with overall incident VTE. However, after controlling for hospitalization for major surgery or medical illness and nursing home confinement, diabetes was no longer associated with VTE. CONCLUSION-: Diabetes mellitus and diabetes complications are not independent risk factors for incident VTE.

AB - OBJECTIVE-: Although diabetes mellitus is reported as a risk factor for venous thromboembolism (VTE), persons with diabetes are frequently hospitalized for medical illness or surgery, or confined to a nursing home, all major VTE risk factors. Consequently, we tested diabetes for an independent association with incident VTE. METHODS AND RESULTS-: Using Rochester Epidemiology Project resources, we identified all Olmsted County, Minn residents who met objective criteria for incident VTE over the 25-year period, 1976 to 2000 (n=1922), and 1 to 2 resident controls per case, matched on age, gender, and length of medical history (n=2115). Complete medical histories in the community were reviewed for previously identified independent VTE risk factors and diabetes-related variables. We tested diabetes and diabetes complications (retinopathy, nephropathy or neuropathy, and ketoacidosis) as potential VTE risk factors, both alone and after adjusting for VTE risk factors. Univariately, diabetes by clinical diagnosis or by stricter criteria (fasting ambulatory blood glucose ≥140 mg/dL or antidiabetic drug therapy), and diabetes complications, were associated with overall incident VTE. However, after controlling for hospitalization for major surgery or medical illness and nursing home confinement, diabetes was no longer associated with VTE. CONCLUSION-: Diabetes mellitus and diabetes complications are not independent risk factors for incident VTE.

KW - Deep vein thrombosis

KW - Diabetes mellitus

KW - Pulmonary embolism

KW - Venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=69849111861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69849111861&partnerID=8YFLogxK

U2 - 10.1161/ATVBAHA.109.189290

DO - 10.1161/ATVBAHA.109.189290

M3 - Article

C2 - 19542020

AN - SCOPUS:69849111861

VL - 29

SP - 1399

EP - 1405

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 9

ER -