Is an aggressive surgical approach to the patient with gastric lymphoma warranted?

C. B. Rosen, J. A. van Heerden, J. K. Martin, L. E. Wold, D. M. Ilstrup

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Abstract

At the Mayo Clinic, from 1970 through 1979, 84 patients (52 males and 32 females) had abdominal exploration for primary gastric lymphoma. All patients were observed a minimum of 5 years or until death. The histological findings for all 84 patients were reviewed. Forty-four patients had 'curative resection', and 40 patients had either biopsy alone or a palliative procedure. The probability of surviving 5 years was 75% for patients after potentially curative resection and 32% for patients after biopsy and palliation (p<0.001). The operative mortality rate was 5% overall and 2% after potentially curative resection. Increased tumor size (p<0.02), increased tumor penetration (p<0.01), and lymph node involvement (p<0.02) decreased the probability of survival, whereas histologic classification did not affect survival. Radiation therapy after surgery did not significantly affect the survival rate for the entire group or the survival rate for patients who had potentially curative resection. Resectability was associated with increased patient survival - independent of other prognostic factors - when our experience was analyzed by the Cox proportional-hazards model (p<0.005). It was concluded that an aggressive surgical attitude in the treatment of primary gastric lymphoma is warranted. The role of radiotherapy remains in question.

Original languageEnglish (US)
Pages (from-to)634-640
Number of pages7
JournalAnnals of Surgery
Volume205
Issue number6
StatePublished - 1987

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Survival
Radiotherapy
Survival Rate
Biopsy
Familial primary gastric lymphoma
Proportional Hazards Models
Neoplasms
Lymph Nodes
Mortality
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Rosen, C. B., van Heerden, J. A., Martin, J. K., Wold, L. E., & Ilstrup, D. M. (1987). Is an aggressive surgical approach to the patient with gastric lymphoma warranted? Annals of Surgery, 205(6), 634-640.

Is an aggressive surgical approach to the patient with gastric lymphoma warranted? / Rosen, C. B.; van Heerden, J. A.; Martin, J. K.; Wold, L. E.; Ilstrup, D. M.

In: Annals of Surgery, Vol. 205, No. 6, 1987, p. 634-640.

Research output: Contribution to journalArticle

Rosen, CB, van Heerden, JA, Martin, JK, Wold, LE & Ilstrup, DM 1987, 'Is an aggressive surgical approach to the patient with gastric lymphoma warranted?', Annals of Surgery, vol. 205, no. 6, pp. 634-640.
Rosen CB, van Heerden JA, Martin JK, Wold LE, Ilstrup DM. Is an aggressive surgical approach to the patient with gastric lymphoma warranted? Annals of Surgery. 1987;205(6):634-640.
Rosen, C. B. ; van Heerden, J. A. ; Martin, J. K. ; Wold, L. E. ; Ilstrup, D. M. / Is an aggressive surgical approach to the patient with gastric lymphoma warranted?. In: Annals of Surgery. 1987 ; Vol. 205, No. 6. pp. 634-640.
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