Irritable bowel syndrome and the perinatal period: lower birth weight increases the risk

D. Raslau, L. M. Herrick, G. R. Locke, C. D. Schleck, A. R. Zinsmeister, A. Almazar, N. J. Talley, Yuri Ann Saito Loftus

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Early life events have been found to be associated with irritable bowel syndrome (IBS) suggesting a role in development of functional disorders. The study aim was to identify potential perinatal risk factors for adult IBS. Methods: Utilizing a population-based nested case–control design, cases who met modified Rome III criteria for IBS and age- and-gender matched controls were identified using responses from prior mailed surveys to a random sample of Olmsted County residents. Medical records of eligible respondents were reviewed for perinatal events of interest. The association of early life events with subsequent case status was assessed using conditional logistic regression. Key Results: Of 3 417 respondents, 513 were born in Olmsted County and 108 met criteria for IBS. Due to missing records, 89 pairs were included in the final analyses. Logistic regression revealed only birth weight as a predictor of IBS. Lower birth weight increased the odds for IBS (OR = 1.54 [95% CI = (1.12, 2.08), p = 0.008]). Median birth weight was 3.35 kg (range: 1.96–5.24) and 3.57 kg (range: 2.18–4.59) for cases and controls, respectively. Maternal age, delivery method, and antibiotic exposure were not associated with IBS status but this study was only powered to detect large odds ratios. Conclusions and Inferences: Lower birth weight was observed as a risk factor for IBS. It is not clear if in utero developmental delays directly lead to IBS or if low birth weight is a prospective marker for subsequent early life problems leading to IBS.

Original languageEnglish (US)
Pages (from-to)1518-1524
Number of pages7
JournalNeurogastroenterology and Motility
Volume28
Issue number10
DOIs
StatePublished - Oct 1 2016

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Irritable Bowel Syndrome
Birth Weight
Logistic Models
Maternal Age
Low Birth Weight Infant
Medical Records
Odds Ratio
Anti-Bacterial Agents

Keywords

  • birth
  • birth weight
  • infancy
  • irritable bowel syndrome
  • risk factors

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Raslau, D., Herrick, L. M., Locke, G. R., Schleck, C. D., Zinsmeister, A. R., Almazar, A., ... Saito Loftus, Y. A. (2016). Irritable bowel syndrome and the perinatal period: lower birth weight increases the risk. Neurogastroenterology and Motility, 28(10), 1518-1524. https://doi.org/10.1111/nmo.12849

Irritable bowel syndrome and the perinatal period : lower birth weight increases the risk. / Raslau, D.; Herrick, L. M.; Locke, G. R.; Schleck, C. D.; Zinsmeister, A. R.; Almazar, A.; Talley, N. J.; Saito Loftus, Yuri Ann.

In: Neurogastroenterology and Motility, Vol. 28, No. 10, 01.10.2016, p. 1518-1524.

Research output: Contribution to journalArticle

Raslau, D, Herrick, LM, Locke, GR, Schleck, CD, Zinsmeister, AR, Almazar, A, Talley, NJ & Saito Loftus, YA 2016, 'Irritable bowel syndrome and the perinatal period: lower birth weight increases the risk', Neurogastroenterology and Motility, vol. 28, no. 10, pp. 1518-1524. https://doi.org/10.1111/nmo.12849
Raslau D, Herrick LM, Locke GR, Schleck CD, Zinsmeister AR, Almazar A et al. Irritable bowel syndrome and the perinatal period: lower birth weight increases the risk. Neurogastroenterology and Motility. 2016 Oct 1;28(10):1518-1524. https://doi.org/10.1111/nmo.12849
Raslau, D. ; Herrick, L. M. ; Locke, G. R. ; Schleck, C. D. ; Zinsmeister, A. R. ; Almazar, A. ; Talley, N. J. ; Saito Loftus, Yuri Ann. / Irritable bowel syndrome and the perinatal period : lower birth weight increases the risk. In: Neurogastroenterology and Motility. 2016 ; Vol. 28, No. 10. pp. 1518-1524.
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