Irreversible electroporation for catheter-based cardiac ablation: a systematic review of the preclinical experience

Alan Sugrue, Vaibhav Vaidya, Chance Witt, Christopher V. DeSimone, Omar Yasin, Elad Maor, Ammar M. Killu, Suraj Kapa, Christopher J. McLeod, Damijan Miklavčič, Samuel J Asirvatham

Research output: Contribution to journalReview article

Abstract

Introduction: Irreversible electroporation (IRE) utilizing high voltage pulses is an emerging strategy for catheter-based cardiac ablation with considerable growth in the preclinical arena. Methods: A systematic search for articles was performed from three sources (PubMed, EMBASE, and Google Scholar). The primary outcome was the efficacy of tissue ablation with characteristics of lesion formation evaluated by histologic analysis. The secondary outcome was focused on safety and damage to collateral structures. Results: Sixteen studies met inclusion criteria. IRE was most commonly applied to the ventricular myocardium (n = 7/16, 44%) by a LifePak 9 Defibrillator (n = 9/16, 56%), NanoKnife Generator (n = 2/16, 13%), or other custom generators (n = 5/16, 31%). There was significant heterogeneity regarding electroporation protocols. On histological analysis, IRE was successful in creating ablation lesions with variable transmurality depending on the electric pulse parameters and catheter used. Conclusion: Preclinical studies suggest that cardiac tissue ablation using IRE shows promise in delivering efficacious, safe lesions.

Original languageEnglish (US)
JournalJournal of Interventional Cardiac Electrophysiology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Cardiac Catheters
Electroporation
Defibrillators
PubMed
Myocardium
Catheters
Safety
Growth

Keywords

  • Arrhythmias
  • Atrial fibrillation
  • Cardiac ablation
  • Catheter ablation
  • Irreversible electroporation
  • Pulsed electric field
  • Translational studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Irreversible electroporation for catheter-based cardiac ablation : a systematic review of the preclinical experience. / Sugrue, Alan; Vaidya, Vaibhav; Witt, Chance; DeSimone, Christopher V.; Yasin, Omar; Maor, Elad; Killu, Ammar M.; Kapa, Suraj; McLeod, Christopher J.; Miklavčič, Damijan; Asirvatham, Samuel J.

In: Journal of Interventional Cardiac Electrophysiology, 01.01.2019.

Research output: Contribution to journalReview article

Sugrue, Alan ; Vaidya, Vaibhav ; Witt, Chance ; DeSimone, Christopher V. ; Yasin, Omar ; Maor, Elad ; Killu, Ammar M. ; Kapa, Suraj ; McLeod, Christopher J. ; Miklavčič, Damijan ; Asirvatham, Samuel J. / Irreversible electroporation for catheter-based cardiac ablation : a systematic review of the preclinical experience. In: Journal of Interventional Cardiac Electrophysiology. 2019.
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AU - DeSimone, Christopher V.

AU - Yasin, Omar

AU - Maor, Elad

AU - Killu, Ammar M.

AU - Kapa, Suraj

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AU - Miklavčič, Damijan

AU - Asirvatham, Samuel J

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