Irreversible electroporation: Evolution of a laboratory technique in interventional oncology

Amy R. Deipolyi, Alexander Golberg, Martin L. Yarmush, Ronald S. Arellano, Rahmi Oklu

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE to tumors, percutaneous nonthermal ablation is possible. The history of IRE, evolution of concepts, theory, biological applications, and clinical data regarding its safety and efficacy are discussed.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalDiagnostic and Interventional Radiology
Volume20
Issue number2
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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