Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus

Hongyan Liu, Thu Le Trinh, Huijia Dong, Robertson Keith, David Nelson, Chen Liu

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Hepatitis C viral infection affects 170 million people worldwide. It causes serious chronic liver diseases. HCV infection has been implicated in iron accumulation in the liver and iron overload has been shown to be a potential cofactor for HCV associated hepatocellular carcinoma progression. The underlying mechanisms are not understood. Human hepcidin, a 25 amino acid peptide mainly produced by hepatocytes, is a key regulator of iron metabolism. Alteration of hepcidin expression levels has been reported in the setting of chronic HCV infection and hepatocellular carcinoma. In this study, we aim to examine the interactions between HCV infection and hepcidin expression in liver cells. We found that hepcidin expression was suppressed in HCV infected cells. The suppressive effect appears to be regulated by histone acetylation but not DNA methylation. Moreover, we found that hepcidin had a direct antiviral activity against HCV replication in cell culture. The antiviral effect is associated with STAT3 activation. In conclusion, hepcidin can induce intracellular antiviral state while HCV has a strategy to suppress hepcidin expression. This may be a novel mechanism by which HCV circumvents hepatic innate antiviral defense.

Original languageEnglish (US)
Article numbere46631
JournalPloS one
Volume7
Issue number10
DOIs
StatePublished - Oct 22 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus'. Together they form a unique fingerprint.

Cite this