Iron and peripheral arterial disease: Revisiting the iron hypothesis in a different light

Gautam Ramakrishna, Thorn W. Rooke, Leslie T. Cooper

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

The relationship between iron status and atherosclerosis has long been a topic of debate in the literature. Despite more than 25 years of research, there is no consensus regarding a causal relationship. To date, the vast majority of studies have focused on iron burden with respect to a hypothesized role in the onset and progression of coronary artery disease. However, the effect of iron in the coronary arterial system may differ mechanistically and therefore clinically from its effect in the peripheral arterial system. This review will summarize the biochemical, pathologic, animal, and clinical research data with respect to iron and atherosclerosis. This background will be expanded upon to provide insights into ongoing studies and paths for future investigations into the role of iron and peripheral arterial disease.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalVascular Medicine
Volume8
Issue number3
DOIs
StatePublished - Dec 1 2003

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Iron
  • Oxidative stress
  • Peripheral arterial disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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