Iris and ciliary body melanomas: Ultrasound biomicroscopy with histopathologic correlation

Flavio A. Marigo, Paul T. Finger, Steven A. McCormick, Raymond Iezzi, K. Esaki, H. Ishikawa, Jeffrey M. Liebmann, Robert Ritch

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Objective: To correlate ultrasound biomicroscopic images of iris and ciliary body melanomas with their histopathologic features. Methods: Ultrasound biomicroscopy was performed in 3 cases of iris melanoma and in 3 cases of ciliary body melanoma. Cross-sectional ultrasound biomicroscopic images were compared with findings from clinical examination and light microscopy to evaluate associations between their histopathologic, surface, and internal ultrasound characteristics. Unique images of intrastomal and obscured posterior tumor margins were visualized by ultrasound biomicroscopy. Results: Results of this study revealed that ultrasound biomicroscopy offers an accurate method to evaluate tumor shape, reflectivity, and local invasion. Neoplastic tissue had only medium echogenicity. Enlarged vessels were correlated to echolucent spaces in the iris stroma. Anterior tumor margins were found within the iris stroma, within the anterior chamber angle, and on the endothelial surface of the cornea. Posterior tumor extension was noted to encroach onto the lens, into the sclera, and serous peripheral retinal detachments were associated with ciliary body tumors. Conclusion: Ultrasound biomicroscopic images correlated well with histopathologic features of anterior uveal melanomas including shape, reflectivity, and local extension.

Original languageEnglish (US)
Pages (from-to)1515-1521
Number of pages7
JournalArchives of Ophthalmology
Volume118
Issue number11
StatePublished - 2000
Externally publishedYes

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Acoustic Microscopy
Ciliary Body
Iris
Melanoma
Neoplasms
Sclera
Anterior Chamber
Retinal Detachment
Cornea
Lenses
Microscopy
Light

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Marigo, F. A., Finger, P. T., McCormick, S. A., Iezzi, R., Esaki, K., Ishikawa, H., ... Ritch, R. (2000). Iris and ciliary body melanomas: Ultrasound biomicroscopy with histopathologic correlation. Archives of Ophthalmology, 118(11), 1515-1521.

Iris and ciliary body melanomas : Ultrasound biomicroscopy with histopathologic correlation. / Marigo, Flavio A.; Finger, Paul T.; McCormick, Steven A.; Iezzi, Raymond; Esaki, K.; Ishikawa, H.; Liebmann, Jeffrey M.; Ritch, Robert.

In: Archives of Ophthalmology, Vol. 118, No. 11, 2000, p. 1515-1521.

Research output: Contribution to journalArticle

Marigo, FA, Finger, PT, McCormick, SA, Iezzi, R, Esaki, K, Ishikawa, H, Liebmann, JM & Ritch, R 2000, 'Iris and ciliary body melanomas: Ultrasound biomicroscopy with histopathologic correlation', Archives of Ophthalmology, vol. 118, no. 11, pp. 1515-1521.
Marigo FA, Finger PT, McCormick SA, Iezzi R, Esaki K, Ishikawa H et al. Iris and ciliary body melanomas: Ultrasound biomicroscopy with histopathologic correlation. Archives of Ophthalmology. 2000;118(11):1515-1521.
Marigo, Flavio A. ; Finger, Paul T. ; McCormick, Steven A. ; Iezzi, Raymond ; Esaki, K. ; Ishikawa, H. ; Liebmann, Jeffrey M. ; Ritch, Robert. / Iris and ciliary body melanomas : Ultrasound biomicroscopy with histopathologic correlation. In: Archives of Ophthalmology. 2000 ; Vol. 118, No. 11. pp. 1515-1521.
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abstract = "Objective: To correlate ultrasound biomicroscopic images of iris and ciliary body melanomas with their histopathologic features. Methods: Ultrasound biomicroscopy was performed in 3 cases of iris melanoma and in 3 cases of ciliary body melanoma. Cross-sectional ultrasound biomicroscopic images were compared with findings from clinical examination and light microscopy to evaluate associations between their histopathologic, surface, and internal ultrasound characteristics. Unique images of intrastomal and obscured posterior tumor margins were visualized by ultrasound biomicroscopy. Results: Results of this study revealed that ultrasound biomicroscopy offers an accurate method to evaluate tumor shape, reflectivity, and local invasion. Neoplastic tissue had only medium echogenicity. Enlarged vessels were correlated to echolucent spaces in the iris stroma. Anterior tumor margins were found within the iris stroma, within the anterior chamber angle, and on the endothelial surface of the cornea. Posterior tumor extension was noted to encroach onto the lens, into the sclera, and serous peripheral retinal detachments were associated with ciliary body tumors. Conclusion: Ultrasound biomicroscopic images correlated well with histopathologic features of anterior uveal melanomas including shape, reflectivity, and local extension.",
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N2 - Objective: To correlate ultrasound biomicroscopic images of iris and ciliary body melanomas with their histopathologic features. Methods: Ultrasound biomicroscopy was performed in 3 cases of iris melanoma and in 3 cases of ciliary body melanoma. Cross-sectional ultrasound biomicroscopic images were compared with findings from clinical examination and light microscopy to evaluate associations between their histopathologic, surface, and internal ultrasound characteristics. Unique images of intrastomal and obscured posterior tumor margins were visualized by ultrasound biomicroscopy. Results: Results of this study revealed that ultrasound biomicroscopy offers an accurate method to evaluate tumor shape, reflectivity, and local invasion. Neoplastic tissue had only medium echogenicity. Enlarged vessels were correlated to echolucent spaces in the iris stroma. Anterior tumor margins were found within the iris stroma, within the anterior chamber angle, and on the endothelial surface of the cornea. Posterior tumor extension was noted to encroach onto the lens, into the sclera, and serous peripheral retinal detachments were associated with ciliary body tumors. Conclusion: Ultrasound biomicroscopic images correlated well with histopathologic features of anterior uveal melanomas including shape, reflectivity, and local extension.

AB - Objective: To correlate ultrasound biomicroscopic images of iris and ciliary body melanomas with their histopathologic features. Methods: Ultrasound biomicroscopy was performed in 3 cases of iris melanoma and in 3 cases of ciliary body melanoma. Cross-sectional ultrasound biomicroscopic images were compared with findings from clinical examination and light microscopy to evaluate associations between their histopathologic, surface, and internal ultrasound characteristics. Unique images of intrastomal and obscured posterior tumor margins were visualized by ultrasound biomicroscopy. Results: Results of this study revealed that ultrasound biomicroscopy offers an accurate method to evaluate tumor shape, reflectivity, and local invasion. Neoplastic tissue had only medium echogenicity. Enlarged vessels were correlated to echolucent spaces in the iris stroma. Anterior tumor margins were found within the iris stroma, within the anterior chamber angle, and on the endothelial surface of the cornea. Posterior tumor extension was noted to encroach onto the lens, into the sclera, and serous peripheral retinal detachments were associated with ciliary body tumors. Conclusion: Ultrasound biomicroscopic images correlated well with histopathologic features of anterior uveal melanomas including shape, reflectivity, and local extension.

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