Ionic conductances in gastrointestinal smooth muscles and interstitial cells of Cajal

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

Ion channels are the unitary elements that underlie electrical activity of gastrointestinal smooth muscle cells and of interstitial cells of Cajal. The result of ion channel activity in the gastrointestinal smooth muscle layers is a rhythmic change in membrane potential that in turn underlies events leading to organized motility patterns. Gastrointestinal smooth muscle cells and interstitial cells of Cajal express a wide variety of ion channels that are tightly regulated. This review summarizes 20 years of data obtained from patch-clamp studies on gastrointestinal smooth muscle cells and interstitial cells, with a focus on regulation.

Original languageEnglish (US)
Pages (from-to)45-84
Number of pages40
JournalAnnual Review of Physiology
Volume61
DOIs
StatePublished - 1999

Keywords

  • Ion channels
  • Patch clamp
  • Review

ASJC Scopus subject areas

  • Physiology

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