Involvement of Medullary Serotonergic Groups in Multiple System Atrophy

Eduardo E. Benarroch; Ann M. Schmeichel; Phillip A. Low; Joseph E. Parisi

doi:10.1002/ana.20021

Involvement of Medullary Serotonergic Groups in Multiple System Atrophy

Eduardo E. Benarroch, Ann M. Schmeichel, Phillip A. Low, Joseph E. Parisi

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71 Scopus citations

Abstract

We sought to determine whether medullary serotonergic neurons were affected in multiple system atrophy (MSA). Immunostaining for tryptophan hydroxylase was performed on serial 50μm sections of the medulla of brains obtained at autopsy from six control subjects, eight subjects with clinical diagnosis of MSA, and four with Parkinson's disease. There was a severe depletion of serotonergic neurons in the nucleus raphe magnus, raphe obscurus, raphe pallidus, and ventrolateral medulla in MSA. Depletion of serotonergic neurons may contribute to impaired control of sympathetic outflow and other abnormalities in MSA.

Original language	English (US)
Pages (from-to)	418-422
Number of pages	5
Journal	Annals of neurology
Volume	55
Issue number	3
DOIs	https://doi.org/10.1002/ana.20021
State	Published - Mar 2004

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "We sought to determine whether medullary serotonergic neurons were affected in multiple system atrophy (MSA). Immunostaining for tryptophan hydroxylase was performed on serial 50μm sections of the medulla of brains obtained at autopsy from six control subjects, eight subjects with clinical diagnosis of MSA, and four with Parkinson's disease. There was a severe depletion of serotonergic neurons in the nucleus raphe magnus, raphe obscurus, raphe pallidus, and ventrolateral medulla in MSA. Depletion of serotonergic neurons may contribute to impaired control of sympathetic outflow and other abnormalities in MSA.",

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AU - Parisi, Joseph E.

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Involvement of Medullary Serotonergic Groups in Multiple System Atrophy

Abstract

ASJC Scopus subject areas

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