Involvement of Medullary Serotonergic Groups in Multiple System Atrophy

Eduardo E. Benarroch, Ann M. Schmeichel, Phillip Anson Low, Joseph E Parisi

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

We sought to determine whether medullary serotonergic neurons were affected in multiple system atrophy (MSA). Immunostaining for tryptophan hydroxylase was performed on serial 50μm sections of the medulla of brains obtained at autopsy from six control subjects, eight subjects with clinical diagnosis of MSA, and four with Parkinson's disease. There was a severe depletion of serotonergic neurons in the nucleus raphe magnus, raphe obscurus, raphe pallidus, and ventrolateral medulla in MSA. Depletion of serotonergic neurons may contribute to impaired control of sympathetic outflow and other abnormalities in MSA.

Original languageEnglish (US)
Pages (from-to)418-422
Number of pages5
JournalAnnals of Neurology
Volume55
Issue number3
DOIs
StatePublished - Mar 2004

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Multiple System Atrophy
Serotonergic Neurons
Tryptophan Hydroxylase
Parkinson Disease
Autopsy
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Involvement of Medullary Serotonergic Groups in Multiple System Atrophy. / Benarroch, Eduardo E.; Schmeichel, Ann M.; Low, Phillip Anson; Parisi, Joseph E.

In: Annals of Neurology, Vol. 55, No. 3, 03.2004, p. 418-422.

Research output: Contribution to journalArticle

Benarroch, Eduardo E. ; Schmeichel, Ann M. ; Low, Phillip Anson ; Parisi, Joseph E. / Involvement of Medullary Serotonergic Groups in Multiple System Atrophy. In: Annals of Neurology. 2004 ; Vol. 55, No. 3. pp. 418-422.
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