TY - JOUR
T1 - Involvement of calcium channels in short-term desensitization of muscarinic receptor-mediated cyclic GMP formation in mouse neuroblastoma cells
AU - El-Fakahany, E.
AU - Richelson, E.
PY - 1980
Y1 - 1980
N2 - Incubation of mouse neuroblastoma cells (clone N1E-115 with Mn2+ resulted in a rapid and transient increase in cyclic GMP formation. This effect appears to be due to an increase in calcium influx because it did not occur in the absence of extracellular calcium or in the presence of verapamil, a calcium transport inhibitor. In addition, Mn2+ inhibited muscarinic receptor-mediated cyclic GMP responses. The ability of Mn2+ to increase cyclic GMP levels was markedly diminished in cells desensitized to the effects of carbamoylcholine, suggesting that this desensitization involves inactivation of calcium entry.
AB - Incubation of mouse neuroblastoma cells (clone N1E-115 with Mn2+ resulted in a rapid and transient increase in cyclic GMP formation. This effect appears to be due to an increase in calcium influx because it did not occur in the absence of extracellular calcium or in the presence of verapamil, a calcium transport inhibitor. In addition, Mn2+ inhibited muscarinic receptor-mediated cyclic GMP responses. The ability of Mn2+ to increase cyclic GMP levels was markedly diminished in cells desensitized to the effects of carbamoylcholine, suggesting that this desensitization involves inactivation of calcium entry.
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U2 - 10.1073/pnas.77.11.6897
DO - 10.1073/pnas.77.11.6897
M3 - Article
C2 - 6256769
AN - SCOPUS:0019179799
SN - 0027-8424
VL - 77
SP - 6897
EP - 6901
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 11 I
ER -