Invivo assessment of systolic and diastolic myocardial stiffness in pigs using 3d cardiac magnetic resonance elastography

Shivaram P. Arunachalam, Arvin Forghanian-Arani, Kevin J. Glaser, Richard Lorne Ehman, Philip A Araoz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Myocardial stiffness is a novel biomarker with both diagnostic and prognostic potential in a range of cardiac diseases such as ischemia or myocardial infarction known to have increased stiffness. Application of Magnetic Resonance Elastography (MRE) to the heart enables measurement of myocardial stiffness in vivo. This study was performed to measure in-vivo myocardial stiffness during systole and diastole in pigs (n=17) using 3D MRE. A custom passive driver was placed on the chest and imaging was performed in prone position on a 1.5 Tesla whole body MR imager (Signa Excite; GE) with a 4-channel coil in oblique plane using ECG-gated spin-echo echo planar imaging sequence at 140 Hz vibration frequency with 5 breath holds of approximately 25 seconds. Systolic and diastolic short-axis acquisition was performed prescribing corresponding time delays observed from a FIESTA cine scan. Acquisition parameters: 1 shot, NEX = 1; TR/TE = 4600/52ms; FOV = 28.8 cm; 96x96 image matrix; 11 continuous 3 mm thick slices with 0 mm spacing, isotropic acquisition; 2 motion-encoding gradient (MEG) pairs; x, y, and z motion-encoding directions; ASSET= 2, and 4 phase offsets. MRE stiffness was obtained using 3D Local Frequency Estimation (LFE) algorithm and a ROI covering the left ventricle was used to report stiffness. The mean stiffness of the myocardium in systole was 5.89±0.34 kPa which was significantly higher (p < 0.01) than diastolic stiffness 3.91 ±0.39 kPa across 17 pigs. The results motivate in-vivo assessment of myocardial stiffness throughout the cardiac cycle and also provide a reference value at 140 Hz vibration frequency to develop pig models with cardiac diseases such as heart failure with preserved ejection fraction (HFpEF) that is known to have increased global stiffness.

Original languageEnglish (US)
Title of host publication54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017
PublisherInternational Society of Automation (ISA)
Volume2017-March
ISBN (Electronic)9781945541193
StatePublished - Jan 1 2017
Event54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017 - Denver, United States
Duration: Mar 31 2017Apr 1 2017

Other

Other54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017
CountryUnited States
CityDenver
Period3/31/174/1/17

Fingerprint

Elasticity Imaging Techniques
swine
Magnetic resonance
magnetic resonance
stiffness
Swine
Systole
Stiffness
Vibration
Heart Diseases
Echo-Planar Imaging
Prone Position
Diastole
Heart Ventricles
systole
Myocardium
Electrocardiography
Reference Values
Thorax
Ischemia

Keywords

  • Cardiac function
  • Diastole
  • Left ventricle
  • Magnetic resonance elastography
  • Myocardial stiffness
  • Systole

ASJC Scopus subject areas

  • Bioengineering
  • Instrumentation
  • Biotechnology
  • Biomedical Engineering

Cite this

Arunachalam, S. P., Forghanian-Arani, A., Glaser, K. J., Ehman, R. L., & Araoz, P. A. (2017). Invivo assessment of systolic and diastolic myocardial stiffness in pigs using 3d cardiac magnetic resonance elastography. In 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017 (Vol. 2017-March). International Society of Automation (ISA).

Invivo assessment of systolic and diastolic myocardial stiffness in pigs using 3d cardiac magnetic resonance elastography. / Arunachalam, Shivaram P.; Forghanian-Arani, Arvin; Glaser, Kevin J.; Ehman, Richard Lorne; Araoz, Philip A.

54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017. Vol. 2017-March International Society of Automation (ISA), 2017.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Arunachalam, SP, Forghanian-Arani, A, Glaser, KJ, Ehman, RL & Araoz, PA 2017, Invivo assessment of systolic and diastolic myocardial stiffness in pigs using 3d cardiac magnetic resonance elastography. in 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017. vol. 2017-March, International Society of Automation (ISA), 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017, Denver, United States, 3/31/17.
Arunachalam SP, Forghanian-Arani A, Glaser KJ, Ehman RL, Araoz PA. Invivo assessment of systolic and diastolic myocardial stiffness in pigs using 3d cardiac magnetic resonance elastography. In 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017. Vol. 2017-March. International Society of Automation (ISA). 2017
Arunachalam, Shivaram P. ; Forghanian-Arani, Arvin ; Glaser, Kevin J. ; Ehman, Richard Lorne ; Araoz, Philip A. / Invivo assessment of systolic and diastolic myocardial stiffness in pigs using 3d cardiac magnetic resonance elastography. 54th Annual Rocky Mountain Bioengineering Symposium, RMBS 2017 and 54th International ISA Biomedical Sciences Instrumentation Symposium 2017. Vol. 2017-March International Society of Automation (ISA), 2017.
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