Invited review: Plasticity and energetic demands of contraction in skeletal and cardiac muscle

Gary C Sieck, Michael Regnier

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Numerous studies have explored the energetic properties of skeletal and cardiac muscle fibers. In this mini-review, we specifically explore the interactions between actin and myosin during cross-bridge cycling and provide a conceptual framework for the chemomechanical transduction that drives muscle fiber energetic demands. Because the myosin heavy chain (MHC) is the site of ATP hydrolysis and actin binding, we focus on the mechanical and energetic properties of different MHC isoforms. Based on the conceptual framework that is provided, we discuss possible sites where muscle remodeling may impact the energetic demands of contraction in skeletal and cardiac muscle.

Original languageEnglish (US)
Pages (from-to)1158-1164
Number of pages7
JournalJournal of Applied Physiology
Volume90
Issue number3
StatePublished - 2001

Fingerprint

Myosin Heavy Chains
Myocardium
Skeletal Muscle
Muscles
Skeletal Muscle Fibers
Myosins
Actins
Protein Isoforms
Hydrolysis
ATP-G-actin

Keywords

  • Actomyosin ATPase
  • Cross-bridge cycling
  • Muscle fiber mechanical properties
  • Muscle remodeling
  • Myosin heavy chain

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Invited review : Plasticity and energetic demands of contraction in skeletal and cardiac muscle. / Sieck, Gary C; Regnier, Michael.

In: Journal of Applied Physiology, Vol. 90, No. 3, 2001, p. 1158-1164.

Research output: Contribution to journalArticle

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